tolbutamide


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Related to tolbutamide: acarbose, metformin

tolbutamide

 [tol-bu´tah-mīd]
a sulfonylurea used as a hypoglycemic in patients with type 2 diabetes mellitus whose blood glucose cannot be controlled by diet and exercise alone. The monosodium salt is used to test for insulinoma and diabetes mellitus.

tolbutamide

/tol·bu·ta·mide/ (tol-bu´tah-mīd) a sulfonylurea used as a hypoglycemic in the treatment of type 2 diabetes mellitus; the monosodium salt is used to test for insulinoma and diabetes mellitus.

tolbutamide

(tŏl-byo͞o′tə-mīd′)
n.
A sulfonylurea drug, C12H18N2O3S, used to treat type 2 diabetes.

TOLBUTamide

[tolbo̅o̅′təmīd]
an oral sulfonylurea antidiabetic.
indications It is prescribed in the treatment of stable type 2 diabetes uncontrolled by diet alone and for some patients changing from insulin to oral therapy.
contraindications Unstable diabetes, serious impairment of renal, hepatic, or thyroid function, pregnancy, or known hypersensitivity to this drug or to other sulfonylurea medications prohibits its use.
adverse effects Among the more serious adverse effects are hypoglycemia and skin reactions. Blood dyscrasias may occur.

tolbutamide

A drug used in the treatment of maturity-onset, non-insulin-dependent DIABETES. A brand name is Rastinon.

tolbutamide

oral hypoglycaemic agent stimulating synthesis and release of endogenous insulin from functional pancreatic islet cells

tolbutamide, (tolbū´təmīd´),

n brand name: Orinase;
drug class: sulfonylurea (first generation) oral antidiabetic;
action: causes functioning beta cells in pancreas to release insulin, leading to drop in blood glucose levels;
use: treatment of type II diabetes mellitus.

tolbutamide

a first generation sulfonylurea derivative, used as an oral hypoglycemic agent in the treatment of diabetes mellitus.

tolbutamide tolerance test
the blood sugar curve after an intravenous injection of the hypoglycemic agent tolbutamide parallels the curve in a glucose tolerance test.
References in periodicals archive ?
minima, only the flower and leaf extracts and tolbutamide tends to bring the fasting blood glucose level towards the normal in the acute study.
The present study was performed to evaluate the potential effect of aprepitant 40 mg on CYP2C9 activity and to evaluate the safety and tolerability of coadministration of aprepitant 40 mg and tolbutamide 500 mg.
At the higher level, the drop was comparable (slightly larger) than that produced by tolbutamide (40.
Acute insulin responses to calcium and tolbutamide do not differentiate focal from diffuse congenital hyperinsulinism.
Recurrent sulfonylurea induced nocturnal hypoglycemia managed with tolbutamide.
Neonatal megakaryocytic hypoplasia is caused by infection with cytomegalovirus (CMV), Toxoplasma, rubella, and human immunodeficiency virus (HIV) and in utero exposure to chlorothiazide diuretics and the oral hypoglycemic tolbutamide.
All patients reduced their insulin dose and began switching to oral sulfonylureas (glyburide in 43, glipizide in 2, gliclazide [not available in the United States] in 2, tolbutamide in 1, and glimepiride in 1) with the goal of either achieving insulin independence or a sulfonylurea dose of at least 0.
xx Actos, Amaryl, Avandamet, Avandia, chlorpropamide, Diabeta, Diabinese, Fortamet, Glipizide, Glipizide ER, Glipizide XL,Glucophage, Glucophage XR, Glucotrol, Glucotrol XL, Glucovance, glyburide, glyburide micronized, glyburide-metformin, Glynase, Glyset, Humalog, Humalog Mix 75/25, Humulin 50/50, Humulin 70/30, Humulin L, Humulin N, Humulin R, Humulin U, Iletin II Lente Pork, Iletin II NPH Pork, Iletin II Regular Pork, Iletin NPH, Lantus, Metaglip, metformin, metformin ER, Micronase, Novolin 70/30, Novolin L, Novolin N, Novolin R, Novolog, Novolog Mix 70/30, Prandin, Precose, Riomet, Starlix, tolazamide, tolbutamide, Tolinase, Velosulin Human BR ED = Erectile dysfunction; ICD-9-CM = International Classification of Diseases, 9th Edition, Clinical Modification; HCTZ = hydrochlorothiazide.
Details of the findings are presented in Molecular Pharmacology, a scientific magazine published by the American Society for Pharmacology and Experimental Therapeutics, under the title "CYP2C76, a novel CYP in cynomolgus monkey, is a major CYP2C in liver, metabolizing tolbutamide and testosterone".
Extended Hildebrand solubility approach: Solubility of tolbutamide, acetohexamide, and sulfisomidine in binary solvent mixtures.
Generic name Brand name acetohexamide Dymelor chlorpropamide Diabinese glimepiride Amaryl glipizide Glucotrol, Glucotrol XL glyburide DiaBeta, Glynase, PresTab, Micronase tolazamide Tolinase tolbutamide Orinase