tobramycin


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tobramycin

 [to″brah-mi´sin]
an aminoglycosideantibiotic produced by Streptomyces tenebrarius and used topically as the base to treat external infections of the eye, by oral inhalation to treat Pseudomonas aeruginosa infections in patients with cystic fibrosis, and intramuscularly or intravenously as the sulfate salt to treat a wide variety of infections.

tobramycin

/to·bra·my·cin/ (to″brah-mi´sin) an aminoglycoside antibiotic derived from a complex produced by Streptomyces tenebrarius, bactericidal against many gram-negative and some gram-positive organisms; also used as the sulfate salt.

tobramycin

Nebcin® A broad-spectrum aminoglycoside antibiotic effective against many gram-negative bacteria, in particular, Pseudomonas infections, unresponsiveness to penicillins or cephalosporins Adverse effects Ototoxicity, neurotoxicity, nephrotoxicity. See Therapeutic drug monitoring.

tobramycin

An antibiotic drug similar in use to Gentamicin, but useful in the treatment of gentamicin-resistant infections. A brand name is Nebcin.

antibiotic 

1. Pertaining to the ability to destroy or inhibit other living organisms.
2. A substance derived from a mould or bacterium, or produced synthetically, that destroys (bactericidal) or inhibits the growth (bacteriostatic) of other microorganisms and is thus used to treat infections. Some substances have a narrow spectrum of activity whereas others act against a wide range of both gram-positive and gram-negative organisms (broad-spectrum antibiotics). Antibiotics can be classified into several groups according to their mode of action on or within bacteria: (1) Drugs inhibiting bacterial cell wall synthesis, such as bacitracin, vancomycin and the β-lactams based agents (e.g. penicillin, cephalosporins (e.g. ceftazidime, ceftriaxone, cefuroxime). (2) Drugs affecting the bacterial cytoplasmic membrane, such as polymyxin B sulfate and gramicidin. (3) Drugs inhibiting bacterial protein synthesis, such as aminoglycosides (e.g. amikacin sulfate, framycetin sulfate, gentamicin, neomycin sulfate and tobramycin), tetracyclines, macrolides (e.g. erythromycin and azithromycin) and chloramphenicol. (4) Drugs inhibiting the intermediate metabolism of bacteria, such as sulfonamides (e.g. sulfacetamide sodium) and trimethoprim. (5) Drugs inhibiting bacterial DNA synthesis, such as nalixidic acid and fluoroquinolones (e.g. ciprofloxacin, levofloxacin, moxifloxacin, norfloxacin and ofloxacin). (6) Other antibiotics such as fusidic acid, the diamidines, such as propamidine isethionate and dibrompropamidine. Syn. antibacterial. See antiinflammatory drug; fusidic acid.

tobramycin (ophthalmic),

n brand name: Tobrax;
drug class: antiinfective;
action: inhibits bacterial protein synthesis;
use: treatment of infection of the eye.

tobramycin

an aminoglycoside antibiotic, similar to kanamycin and neomycin, produced by cultures of Streptomyces tenebrarius. Used as the sulfate.
References in periodicals archive ?
Overall, no clinically relevant or statistically significant differences in adverse events were observed between the AzaSite and tobramycin groups.
In this way, the entire load of tobramycin contained in the Fluidosomes(TM) is released into the bacterial cell.
PARI conducted a Phase I clinical trial as a randomized, open label, crossover, single-dose deposition study of PARI Tobramycin 100 in an Investigational eFlow Nebulizer System versus TOBI/LC PLUS in 16 cystic fibrosis patients, including 8 adults and 8 children.
In the case of Fluidosome-tobramycin, the interaction between tobramycin and the microbial cell is triggered when the liposomes attach to the outer cell membrane.
Delivering an anti-infective drug like tobramycin quickly and directly into an infected lung is a logical way to treat CF patients," said John Patton, Ph.
Our lead product ARB-CF0223 - also known as Fluidosome(R) tobramycin - is expected to generate a peak annual turnover of approx.
Preliminary results based on patients who have completed the study from the combined AzaSite and tobramycin groups indicate that both ophthalmic solutions were well tolerated by the patients.
coli susceptible to amikacin, gentamicin, tobramycin, piperacillin/ tazobactam, trimethoprim/ sulfamethoxazole, imipenem, and nitrofurantoin.
In the same form synergism between chlorpromazine and kanamycin, amikacin and tobramycin was observed, indicating the involvement of an efflux system.
Tobramycin, the antibiotic routinely used against the microbes, can control, but not efficiently eliminate Pseudomonas established on CF airway cells.
Tobramycin is an aminoglcoside with an extended spectrum capable of treating infections with gentamicin resistant bacteria.