tizanidine


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tizanidine

 [ti-zan´ĭ-dēn″]
a short-acting antispasmodic used in the acute and intermittent treatment of spasticity, such as that associated with multiple sclerosis or spinal cord injury; administered orally as the hydrochloride salt.

tizanidine

/ti·zan·i·dine/ (ti-zan´ĭ-dēn″) an antispastic used as the hydrochloride salt in the treatment of spasticity related to multiple sclerosis or spinal cord injury.

tizanidine

a skeletal muscle relaxant and a2-adrenergic agonist.
indications It is used in the acute/intermittent management of increased muscle tone associated with spasticity.
contraindication Known hypersensitivity to this drug prohibits its use.
adverse effects Adverse effects include dry mouth, vomiting, increased ALT, abnormal liver function studies, constipation, somnolence, dizziness, speech disorder, dyskinesia, nervousness, hallucination, psychosis, urinary tract infection, blurred vision, urinary frequency, flulike syndrome, pharyngitis, and rhinitis.

tizanidine

A muscle relaxant drug used to treat muscle spasm in multiple sclerosis or spinal injury. This drug is said to reduce spasm without reducing strength. A brand name is Zanaflex.
References in periodicals archive ?
8,9] Tizanidine is another muscle relaxant acts on imidazoline and [alpha]2-adrenergic receptor.
Patients with a lack of response at the end of second week or intolerable side effects to either of the Tizanidine drugs were transferred to Gabapentin.
These drugs are effective, but come with side effects, including drowsiness, nausea and diarrhea; and baclofen, tizanidine and diazepam can impair liver function.
The company said that tizanidine hydrochloride capsules are an authorised generic version of ZANAFLEX CAPSULES (tizanidine hydrochloride).
Ayoub guilty of four counts of assault and battery with a dangerous weapon (car), assault and battery on a police officer, carrying a firearm without a license, possession of cocaine, possession of tizanidine, driving so as to endanger, unlawful possession of ammunition, failure to stop for a police officer and failure to surrender a revoked firearm license.
Concomitant use of tizanidine with the antidepressant fluvoxamine or the antibiotic ciprofloxacin is now contraindicated.
These changes, which were added to the contraindications and warnings section of the tizanidine label, were approved by the Food and Drug Administration last summer, at which time, the agency asked the company to issue the letter to communicate the information to health care professionals.
Some studies have suggested that tizanidine has pain relief properties in addition to its antispasticity effects (Elovic, 2001).
Tizanidine (Zanaflex [R]) is the first new medication for muscle spasticity to be approved by the Food and Drug Administration (FDA) in more than 20 years.
Other therapies for treating chronic daily headache include the skeletal muscle relaxant tizanidine (Zanaflex), which was studied in an industry-sponsored, double-blind, placebo-controlled trial of 92 patients.
RANK COST DRUG NAME 2003 2002 INCREASE * Oxycontin 1 1 15% Neurontin 2 3 12% Celebrex 3 2 12% Hydroco/Apap 4 5 12% Vioxx 5 4 6% Duragesic 6 6 14% Bextra 7 11 33% Carisoprodol 8 7 8% Ambien 9 9 14% Skelaxin 10 13 29% Lidoderm 11 22 12% Tizanidine 12 37 60% Cyclobenzapr 13 12 11% Tramadol Hcl 14 35 30% Actiq 15 32 55% Ultracet 16 19 23% Percocet 17 21 30% Ranitidine 18 27 26% Propo-N/Apap 19 14 -3% Effexor Xr 20 17 13% Naproxen 21 16 17% Topamax 22 24 22% Morphine Sul 23 29 -1% Zoloft 24 18 6% Wellbutrin 25 31 3% Sub-Total Top 25 12% * Change in the average prescription cost in the calendar year for claimants receiving the drug.
In addition, the dose or timing of medications that reduce spasticity, such as baclofen (Lioresal) and tizanidine (Zanaflex), may need to be adjusted.