tissue proteinase

tissue proteinase

One of a range of enzymes that bring about controlled protein breakdown in a wide range of developmental, physiological and pathological processes. These enzymes are active in such processes as embryogenesis, angiogenesis, blood coagulation, fibrinolysis and inflammation. Over-expression of some of the proteinases has been implicated in a range of pathologies, especially connective tissue disorders such as rheumatoid arthritis in which collagen breakdown is an important factor.
References in periodicals archive ?
Administration of the Vth isoform of trypsin-like proteinases inhibitor, its protective effect could be manifested not only through their blockade and inhibition of infection, but also due to the parallel inhibition of tissue proteinases involved in the reactions of immune inflammation, which contributes to viral lung damage.