tissue factor pathway inhibitor


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tissue factor pathway inhibitor

(extrinsic factor) lipoprotein-associated coagulation inhibitor Hematology A coagulation factor X-dependent inhibitor of the factor VIIa/tissue factor complex; it is a plasma lipoprotein that regulates procoagulant effects of tissue factor; with Ca2+ and phospholipid, TFPI binds to and inhibits either free factor Xa or factors Xa and VIIa when associated with tissue factor-factor VIIa-Xa complex
References in periodicals archive ?
Plasma levels of total tissue factor pathway inhibitor are significantly related with the presence and severity of CAD.
Soluble tissue factor and tissue factor pathway inhibitor in cardiovascular disease.
Prognostic value of plasma tissue factor and tissue factor pathway inhibitor for cardiovascular death in patients with coronary artery disease: the AtheroGene study.
Further investigations of lupus anticoagulant interference in a functional assay for tissue factor pathway inhibitor.
The carboxy terminus of tissue factor pathway inhibitor is required for interacting with hepatoma cells in vitro and in vivo.
Tissue factor pathway inhibitor, natural coagulation inhibitors and hemostatic activation markers in patients with acute coronary syndromes.
Impact of native VLDL on tissue factor pathway inhibitor in endothelial cells and interactions between TFPI and lipoprotein lipase.
The company's expertise has also led to the discovery of new molecules, including analogs of 2ME2, peptides of tissue factor pathway inhibitor (TFPI), and inhibitors of fibroblast growth factor-2 and proteinase activated receptor-2.
The major effect of the procoagulant inhibitors, anti-thrombin (AT), activated protein C (APC), and tissue factor pathway inhibitor (TFPI) on inflammation is to:
tissue factor pathway inhibitor (TFPI), an endogenous anticoagulant molecule, specifically inhibits the growth of endothelial cells, which makes it an appropriate candi-date for development as an antiangiogenic drug
Other modifiers of the rate of thrombin generation are the inhibitors: tissue factor pathway inhibitor, antithrombin, and other proteinase inhibitors.
Results indicate that PI-88 is a strong activator of heparin cofactor II (HCII) but not antithrombin III and that PI-88 exhibits very potent release of tissue factor pathway inhibitor (TFPI) in vivo.