tissue factor pathway inhibitor


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tissue factor pathway inhibitor

(extrinsic factor) lipoprotein-associated coagulation inhibitor Hematology A coagulation factor X-dependent inhibitor of the factor VIIa/tissue factor complex; it is a plasma lipoprotein that regulates procoagulant effects of tissue factor; with Ca2+ and phospholipid, TFPI binds to and inhibits either free factor Xa or factors Xa and VIIa when associated with tissue factor-factor VIIa-Xa complex
References in periodicals archive ?
The major effect of the procoagulant inhibitors, anti-thrombin (AT), activated protein C (APC), and tissue factor pathway inhibitor (TFPI) on inflammation is to:
tissue factor pathway inhibitor (TFPI), an endogenous anticoagulant molecule, specifically inhibits the growth of endothelial cells, which makes it an appropriate candi-date for development as an antiangiogenic drug
These data demonstrate that structure-function studies have yielded novel synthetic peptides with significantly better antiangiogenic activity in preclinical models than a peptide fragment of tissue factor pathway inhibitor.
a clinical-stage pharmaceutical company developing therapeutics for treatment of anemia and cancer, today announced that they have entered into a research collaboration for the synthesis and development of novel peptides that mimic certain fragments of tissue factor pathway inhibitor (TFPI).
Tifacogin, developed by Chiron, is a recombinant form of tissue factor pathway inhibitor, or TFPI, a naturally occurring protein in the body.
a biopharmaceutical company focusing on the research and development of small molecule therapeutics, today announced that it identified a peptide fragment of Tissue Factor Pathway Inhibitor (TFPI), a naturally occurring anti-coagulant protein, that blocks tumor growth and angiogenesis in in vivo models.