tissue activator

tissue activator

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13 Birn14 and Nusair15 propose that excess trauma to the bone causes inflammation of the bone marrow and results in direct tissue activator release into alveolus and predis-pose to dry socket.
When direct tissue activators are released after trauma to the alveolar bone cells, plasminogen (which is laid down in the fibrin network as it is formed) is converted to plasmin, resulting in the clot dissolution by disintegration of fibrin.