tight junction


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Related to tight junction: gap junction, Desmosomes, Adherens junction

zo·nu·la oc·clu·'dens

tight junctions formed by the fusion of integral proteins of the lateral cell membranes of adjacent epithelial cells, limiting transepithelial permeability.

tight junction

[tīt]
Etymology: ME, thight, strong; L, jungere, to join
the zonula occludens of the junctional complex between cells in which the plasma membranes of adjacent cells are in direct contact and where there is no intercellular space.
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Tight junction

tight junc·tion

(tīt jŭngk'shŭn)
An intercellular junction between epithelial cells in which the outer leaflets of lateral cell membranes fuse to form a variable number of parallel interweaving strands that greatly reduce transepithelial permeability to macromolecules, solutes, and water through the paracellular route.

tight junction 

Refers to cells in which their membranes are fused rather than separated by a small extracellular space. The movement of substances through that space is restricted. Syn. zonulae occludentes. See blood-brain barrier.

tight junction

a cell junction in which there is no intercellular space between cell membranes and so is impermeable. See also cell junction.
References in periodicals archive ?
5 and 6 indicated that the permeability of phenylethanoid glycosides in Fructus Forsythiae extract so with that in monomers was mainly restricted by the tight junctions.
These results suggested that GLP-2 improves intestinal tight junction expression in weaned pigs through MAPK signaling pathway.
It is meaning that effect of probiotic LIS 20506 plays on transcription process through by the expression of Occludin and ZO-1 mRNA of intestinal tight junction.
Probiotic mixture VSL#3 protects the epithelial barrier by maintaining tight junction protein expression and preventing apoptosis in a murine model of colitis.
MicroRNA-212 is thought to downregulate zonula occludens-1 (ZO-1) protein, a major component of the tight junctions that regulate intestinal permeability.
Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin.
The images showed that when a virus sticks to this decay-accelerating factor (DAF), those combination particles clump together and then travel toward the tight junction.
Sertoli cell tight junction dynamics: Their regulation during spermatogenesis," Biology of Reproduction 68(4): 1087-1097.
Innumerable endothelial tight junctions in the BBB function to prevent the passage of large soluble molecules into the CNS.
To analyze the change of tight junction proteins, we examined the expression of ZO-1, occludin and claudin-3 in IPEC-J2 cells which were pretreated with LTA-BS or B.