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ticlopidine hydrochloride |
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ticlopidine hydrochloride Ticlid Pharmacologic class: Platelet aggregation inhibitor Therapeutic class: Antiplatelet agent Pregnancy risk category B FDA Boxed Warning• Drug may cause life-threatening hematologic adverse reactions, including neutropenia, agranulocytosis, thrombotic thrombocytopenic purpura (TTP), and aplastic anemia. Such reactions may arise within several days of starting therapy. TTP incidence peaks after about 3 to 4 weeks; neutropenia, at approximately 4 to 6 weeks; and aplastic anemia, after about 4 to 8 weeks. Thereafter, incidence of hematologic reactions declines. ActionInhibits release of first and second phases of adenosine diphosphate-induced effects on platelet aggregation, preventing thrombus formation AvailabilityTablets: 250 mg ⊘Indications and dosages ➣ To reduce risk of thrombotic cerebrovascular accident when aspirin is ineffective or intolerable Adults: 250 mg P.O. b.i.d. with meals ➣ Adjunctive therapy to prevent subacute stent thrombosis in patients with implanted coronary stents Adults: 250 mg P.O. b.i.d. with meals, given with antiplatelet doses of aspirin for up to 30 days after successful stent implantation Dosage adjustment• Renal impairment Off-label uses• Chronic arterial occlusion Contraindications• Hypersensitivity to drug PrecautionsUse cautiously in: Administration• Give with meals.
Adverse reactionsCNS: dizziness, headache, weakness, intracerebral bleeding EENT: conjunctival hemorrhage, tinnitus, epistaxis GI: nausea, vomiting, diarrhea, full sensation, GI pain, dyspepsia, flatulence, anorexia, GI bleeding GU: hematuria Hematologic: ecchymosis, eosinophilia, purpura, TTP, thrombocytosis, neutropenia, agranulocytosis, bone marrow depression Skin: rashes, bruising, pruritus, urticaria Other: pain, posttraumatic or perioperative bleeding InteractionsDrug-drug. Antacids: decreased ticlopidine blood level Aspirin: potentiation of aspirin's effect on platelets Cimetidine (long-term use): reduced ticlopidine clearance Digoxin: slightly decreased digoxin blood level Phenytoin: increased phenytoin blood level, greater risk of toxicity Theophylline: decreased theophylline clearance, greater risk of toxicity Vitamin A: altered anticoagulant effects Drug-diagnostic tests. Alanine aminotransferase, alkaline phosphatase, aspartate aminotransferase: increased levels Granulocytes, neutrophils, platelets, white blood cells: decreased counts Liver function tests: abnormal results Drug-food. Any food: increased ticlopidine absorption Drug-herbs. Alfalfa, anise, arnica, astragalus, bilberry, black current seed oil, bladderwrack, bogbean, boldo, borage oil, buchu, capsacin, cat's claw, celery, chapparal, cinchona bark, clove oil, coenzyme Q10, dandelion, dong quai, evening primrose oil, fenugreek, feverfew, garlic, ginger, gingko, guggal, papaya extract, red clover, rhubarb, safflower oil, skullcap, St. John's wort, tan shen: altered anticoagulant effects Patient monitoring☞ Closely monitor coagulation studies and CBC with white cell differential. Watch for evidence of bleeding tendency and blood dyscrasias. Patient teaching• Tell patient to take with meals, but not within 2 hours of antacids. Want to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit the webmaster's page for free fun content. |
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Ticlopidine hydrochloride was put on sale in Japan in 1981 and about 1 million people are taking it each year. NEW DRUG MORE EFFECTIVE WITH STROKES THAN ASPIRIN Ticlopidine hydrochloride, a recently developed drug, has been proven to be more effective in preventing strokes than aspirin or placebos, according to two recent studies. Subsequent to the quarter's end, FDA tentative approvals have been received for Famotidine (3 strengths), Ketoconazole and Ticlopidine Hydrochloride. |
ticlopidine hydrochloride |
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