thyrotoxic crisis

thyrotoxic crisis

n.

A sudden worsening of thyrotoxicosis following shock, injury, or thyroidectomy. Also called thyroid crisis, thyroid storm.

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thyrotoxic crisis.

See thyroid crisis.

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thyrotoxic

marked by toxic activity of the thyroid.

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thyrotoxic crisis

a fulminating increase in all the clinical signs of thyrotoxicosis.

thyrotoxic heart disease

heart disease associated with hyperthyroidism, marked by atrial fibrillation, cardiac enlargement and congestive heart failure. Most commonly seen in association with hyperthyroidism in aged cats. Called also thyrocardiac disease.

thyrotoxic storm

thyrotoxic crisis.

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thyrotoxic crisis

Thyroid crisis, thyrotoxic storm Endocrinology A hypermetabolic state superimposed on hyperthyroidism, often occurring in Grave's disease–especially if untreated, less common in toxic multinodular goiter, and rarely in Hashimoto's disease/Hashitoxicosis Etiology/'triggers' Infection–eg, streptococcal pharyngitis, thromboembolism, surgery, physical or mental stress, parturition, withdrawal from thyroid-blocking drugs Clinical Sx of hyperthyroidism–eg, weight loss, heat intolerance, myasthenia, ↓ concentration, CHF, PE, restlessness, diarrhea, diaphoresis, palpitations which, when accompanied by 'triggers,' become a life-threatening hypermetabolism, characterized by hyperthermia, tachycardia, cardiac, hepatic and cerebral dysfunction, death Lab ↑ T₄, ↑ T₃, ↓ cholesterol Management ↓ Hypermetabolism, inhibit T₃/T₄ release with iodine, block T₃/T₄ synthesis with propylthiouracil and other anti-thyroid agents, block adrenergic neurotransmission with beta blockers and glucocorticoids to 'cover' for functional hypoadrenalism. See Euthyroid sick syndrome, Hashimoto's disease, Hashitoxicosis, Thyrotoxicosis.