However, thymine dimer
repair was markedly reduced in mice lacking the VDR, indicating that these mice have defective DNA repair mechanisms in UV-induced damage.
Compared with placebo, treated individuals with low baseline MED had a 50% reduction in epidermal sunburned (apoptotic) cells and nearly a 60% reduction in DNA damage, as measured by thymine dimer formation.
Clearly, it has the propensity to prevent cellular damage, as measured by sunburned cells and thymine dimers.
This failure ultimately leads to permanent damage to the DNA--a gene mutation known as a thymine dimer.
These are usually of the thymine dimer type, implicating UVB as the cause.
Barton has found that electron transfer can fix a mutation known as a thymine dimer
, in which two thymines on the same DNA strand bond together.
Upon irradiation with ultraviolet (UV) light, two adjacent structures--thymines--along a strand of DNA may fuse into a thymine dimer
Specifically, UV-C light causes damage to the nucleic acid of microorganisms by the formation of lethal thymine dimers
on the microbial DNA.
Effect of Intense pulsed-light exposure on lipid peroxides and thymine dimers
in human skin in vivo.
Tina Alster says "Remergent DNA Repair helps restore thymine dimers
, which are pieces of DNA broken by UV exposure.
According to company executives, efficacy tests have demonstrated DN-AGE LS 9653's ability to protect both nuclear and mitochondrial DNA, reducing the formation of thymine dimers
caused by UVB absorption and stimulating the natural DNA repair process in skin cells.
Prevent the formation of thymine dimers
-- DNA mutations that can lead to skin cancer.