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thymidine kinase

   Also found in: Acronyms, Wikipedia 0.01 sec.
thymidine kinase,
an enzyme of the transferase class that catalyzes a phosphorylation reaction of pyrimidine salvage and phosphorylation of drugs, such as acyclovir and ganciclovir, into a form that will be active against viruses.
thymidine kinase 
an enzyme of the transferase class that catalyzes a phosphorylation reaction of pyrimidine salvage as well as phosphorylation of drugs such as acyclovir and ganciclovir into a form that will be active against viruses.
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For the study, the researchers used a combined gene therapeutic approach, using one protein (Flt3L) to draw dendritic cells from bone marrow into the brain tumors, and a second protein (Herpes Symplex type I Thymidine Kinase, or TK), combined with the antiviral gancyclovir to kill tumor cells and elicit long-term survival.
Scientists uncover gene therapy to eliminate brain tumours by Asian News International
These substances belong to the synthetic nucleoside analogues interfering with viral DNA replication after activation by viral thymidine kinase.
Comparative in vitro study on the anti-herpetic effect of ... by Schnitzler, P.; Nolkemper, S.; Stintzing, F.C.; Reichling, J. / Phytomedicine: International Journal of Phytotherapy & Phytopharmacology
Subsequently, F-18 FLT is phosphorylated by thymidine kinase 1 (TK1) into F-18 FLT-monophosphate, after which it is trapped in the cell (Figure 7).
PET/CT neuroimaging applications for epilepsy and cerebral neoplasm by Mountz, James M. / Applied Radiology
 
 
 
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