thromboxane


Also found in: Dictionary, Acronyms, Encyclopedia, Wikipedia.
Related to thromboxane: leukotriene, prostacyclin, arachidonic acid, Thromboxane synthase

thromboxane

 [throm-bok´sān]
an intermediate in the metabolic pathway of arachidonic acid, formed from prostaglandin endoperoxides, and released from suitably stimulated platelets; the unstable form, thromboxane A2, is a potent inducer of platelet aggregation and constrictor of arterial smooth muscle.

throm·box·ane

(throm-bok'sān),
The formal parent of the thromboxanes; prostanoic acid in which the -COOH has been reduced to -CH3 and an oxygen atom has been inserted between carbons 11 and 12.

thromboxane

/throm·box·ane/ (-bok´sān) either of two compounds, one designated A2 and the other B2. Thromboxane A2 is synthesized by platelets and is an inducer of platelet aggregation and platelet release functions and is a vasoconstrictor; it is very unstable and is hydrolyzed to thromboxane B2.

thromboxane

(thrŏm-bŏk′sān)
n.
Any of several compounds, originally derived from prostaglandin precursors in platelets, that stimulate aggregation of platelets and constriction of blood vessels.

thromboxane

any of several compounds synthesized by platelets and other cells that cause platelet aggregation and vasoconstriction.

thromboxane (thrôm·bôkˑ·sān),

n one of a pair of compounds that effectively induces platelet aggregation.

thromboxane

an intermediate in the metabolic pathway of arachidonic acid, formed from prostaglandin endoperoxides, and released from suitably stimulated platelets; the unstable form, thromboxane A2, is a potent inducer of platelet aggregation and constrictor of arterial smooth muscle.
References in periodicals archive ?
Thromboxane A(2) regulation of endothelial cell migration, angiogenesis, and tumor metastasis.
Lack of statistical significance of in vivo modulation of platelet COX-1 activity due to ASA ingestion in 12 of the 28 individuals tested could be attributed to varying interdonor functionality of thromboxane, [P2Y.
bleeding, a tendency associated with drugs that block thromboxane or ADP
Activated platelets produce COX-1-dependent thromboxane A2, which acts as a platelet agonist and vasoconstrictor (prothrombotic).
It reduces the formation of an inflammatory messaging molecule known as thromboxane A2 as well.
Baynas Tablet is an agent that antagonizes prostaglandin D2 and thromboxane A2 receptors, which cause allergic rhinitis.
7) The unbalance in platelet redox-state and the increased thromboxane [B.
Aspirin irreversibly inhibits cyclooxygenase (COX)-1 by acetylation of serine-530, which is close to the active site, and thereby affects platelet-dependent thromboxane [A.
Unless you've had a lab test called aggregometry, or a specific urine test that measures thromboxane, you won't know whether or not it's working.
Thromboxane mediates diapedesis after ischemia by activation of neutrophil adhesion receptors interacting with basally expressed intercellular adhesion molecule-1.
Nonsteroidal anti-inflammatory drugs reduce pain and inflammation by inhibiting cyclooxegenase, an enzyme in the pathway for formation of prostaglandins, and thromboxane.