thromboplastin


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Related to thromboplastin: Prothrombin time

thromboplastin

 [throm″bo-plas´tin]
tissue thromboplastin factor III, a coagulation factor derived from several different sources in the body, such as brain and lung; it is important in the formation of extrinsic prothrombin converting principle in the extrinsic pathway of coagulation. Called also tissue factor. See also activated partial thromboplastin time.

throm·bo·plas·tin

(throm'bō-plas'tin),
A substance present in tissues, platelets, and leukocytes necessary for the coagulation of blood; in the presence of calcium ions thromboplastin is necessary for the conversion of prothrombin to thrombin, an important step in coagulation of blood. It is now generally believed that thromboplastin activity may be developed through blood (intrinsic) or tissue (extrinsic) systems. Tissue thromboplastin (factor III) interacts with factor VII and calcium to activate factor X; active factor X combines with factor V in the presence of calcium and phospholipid to produce thromboplastin activity (also commonly called thromboplastin).

thromboplastin

/throm·bo·plas·tin/ (-plas´tin) coagulation factor III.
tissue thromboplastin  coagulation factor III.

thromboplastin

(thrŏm′bō-plăs′tĭn)
n.
A protease that converts prothrombin to thrombin in the early stages of blood clotting. Also called thrombokinase.

thromboplastin

a plasma protein that initiates the clotting process by converting prothrombin to thrombin in the presence of calcium ions.

throm·bo·plas·tin

(throm'bō-plas'tin)
A substance present in tissues, platelets, and leukocytes necessary for the coagulation of blood; in the presence of calcium ions, thromboplastin is necessary for the conversion of prothrombin to thrombin, an important step in blood coagulation.
Synonym(s): platelet tissue factor, thrombokinase.

thromboplastin

Blood clotting factor III, an obsolete term referring to what is now known to be several blood clotting factors operating together.

thromboplastin

see BLOOD CLOTTING.

Thromboplastin

A protein in blood that converts prothrombin to thrombin.
Mentioned in: Prothrombin Time

thromboplastin

; thrombokinase catalyst (in tissues, platelets, leukocytes) which, in presence of calcium ions, aids conversion of prothrombin to thrombin

throm·bo·plas·tin

(throm'bō-plas'tin)
A substance present in tissues, platelets, and leukocytes necessary for the coagulation of blood.
Synonym(s): platelet tissue factor, thrombokinase.

thromboplastin (throm´bōplas´tin),

n a substance necessary to the coagulant activity of tissue extracts; also has been referred to as the direct activator of prothrombin and as a substance from plasma, platelets, and tissues that initiates thromboplastic activity in blood coagulation. See also thromboplastin, extrinsic.
thromboplastin, activated,
n See thromboplastin, extrinsic.
thromboplastin, cofactor of,
n See factor V.
thromboplastin, extrinsic,
n a direct prothrombin activator formed by the interaction of brain extracts, factors V and VII, and factor IV calcium (Ca++).
thromboplastin, incomplete,
n tissue thromboplastin.
thromboplastin, intrinsic (plasma thromboplastin, intrinsic prothrombin activator),
n a prothrombin activator formed from interaction of blood coagulation factors V, VIII, IX, and X and factor IV calcium (Ca++) with a foreign surface.
thromboplastin, partial time (PTT),
n a blood test used to determine von Willebrand disease, hemophilia, and to monitor anticoagulant medications. Normal coagulation time is 68 to 82 seconds. An updated form of the test, activated partial thromboplastin time (APTT), is replacing PTT.
thromboplastin, tissue,
n a factor in tissue extract responsible for coagulation of blood.

thromboplastin

a substance in blood and tissues which, in the presence of ionized calcium, aids in the conversion of prothrombin to thrombin. Extrinsic and intrinsic thromboplastin are formed as the result of the interaction of different clotting factors; the factors that combine to form extrinsic thromboplastin are not all derived from intravascular sources, whereas those that form intrinsic thromboplastin are.

activated partial thromboplastin time
see activated partial thromboplastin time.
extrinsic thromboplastin
the prothrombin activator formed as a result of interaction of coagulation factors III, VII, and X which, with factor IV, aids in the formation of thrombin.
thromboplastin generation time (TGT)
evaluates the first stage in blood coagulation by measuring the efficiency of prothrombinase formation.
intrinsic thromboplastin
the prothrombin activator formed as a result of interaction of coagulation factors V, VII, IX, X, XI and XII and platelet factor 3 (PF-3), which, with factor IV, aids in the conversion of prothrombin to thrombin.
plasma thromboplastin antecedent (PTA)
clotting factor XI; deficiency occurs in cattle and dogs, causing mild to severe bleeding tendencies called hemophilia C.
plasma thromboplastin component (PTC)
clotting factor IX; deficiency causes christmas disease. Called also Christmas factor, antihemophilic factor B, autoprothrombin II.
thromboplastin time
see activated partial thromboplastin time.
tissue thromboplastin
factor III, a material derived from several sources in the body (e.g. brain, lung), and is important in the formation of extrinsic prothrombin converting principle in the extrinsic pathway of blood coagulation. Called also tissue factor.
References in periodicals archive ?
The median results for (A) prothrombin time (PT) and (B) activated partial thromboplastin time (aPTT) in each group are displayed in the upper part of the box plot.
18) Because neither partial thromboplastin nor a phospholipid substitute is added to the sample, coagulation depends on the presence of adequate endogenous amounts of platelet phospholipids in the sample.
In addition to demographic information, we examined data on the indications for PDT and each patient's coagulation status, including three independent variables of interest: prothrombin time (PT), partial thromboplastin time (PTT), and platelet count.
Prothrombin time and partial thromboplastin time tests of smokers and non-smokers did not significantly vary based on their age and sex (tables 3 and 4).
Thromboplastin time/Quick test (TPT): After addition of human placenta thromboplastin and calcium chloride, thrombin is formed from prothrombin in the plasma via the so-called extrinsic coagulation pathway.
This is important because you wont pic up problems with gingo with prothrombin time or partial thromboplastin time testing.
I guessed they had standardized their thromboplastin, or whatever the substrate was.
A complete blood count, basic metabolic panel, liver function tests, activated partial thromboplastin time, prothrombin time/international normalized ratio, and amylase and lipase levels were within normal limits (Table).
6 Troponin I, ng/mL ND ND Coagulation Prothrombin time, s ND ND International normalized ratio, s ND ND Partial thromboplastin time, s ND ND Dimerized plasmin fragment, ng/mL ND ND Patient value, day of hospitalization ([dagger]) Test 4 5 Hematologic White blood cell count, x [10.
6) Although diluted Russell viper venom time and activated partial thromboplastin time (aPTT) sensitized with silica and low phospholipid concentration are primarily recommended, diluted prothrombin time (dPT) using diluted Innovin reagent (human recombinant thromboplastin; Siemens, Marburg, Germany) also provides an inexpensive assay with high sensitivity and high negative predictive value.
5 s (RI, 9-13 s); activated partial thromboplastin time, 31.

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