thromboangiitis


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Related to thromboangiitis: Buerger's disease

thromboangiitis

 [throm″bo-an″je-i´tis]
inflammation of a blood vessel (vasculitis) with thrombosis.
thromboangiitis obli´terans a disease affecting the medium-sized blood vessels, particularly the arteries of the lower limbs, which can cause severe pain and in serious cases lead to gangrene. The name refers to the clotting, pain, and inflammation occurring in this disease and to the fact that it can obliterate, or destroy, blood vessels. The cause has been thought to be excessive use of tobacco over a long period of time, and the number of cases has diminished strikingly in recent years. The intense pain is caused by thrombosis (formation of blood clots) in the lining of the arteries; when the clots grow larger, the blood flow slows and may stop entirely. Since every part of the body depends on the continuous flow of blood, affected areas such as fingers and toes, for example, soon begin to atrophy or develop ulcers. If the causes of the disease are not completely arrested, amputation may be necessary.



To treat the disease, the patient must stop smoking at once and entirely. This generally results in the partial healing of the affected membrane with a renewed flow of blood. However, more blood may have to be brought to damaged tissue by surgical methods of channeling detours or making canals in the clot itself. Sympathectomy may be tried to prevent any vasospastic component. Minor amputations of gangrenous tissue are often needed.

Special exercises called buerger-allen exercises are sometimes used to empty the engorged blood vessels and stimulate collateral circulation. These exercises can be done at home by patients and are usually prescribed to be done several times during the day. Patients are also instructed to avoid wearing any tight clothing, such as tight girdles, rolled garters, constricting belts, and other items that may impair circulation. They should also avoid sitting or standing in one position for long periods of time. Care should be used in the selection of shoes and stockings so that they fit properly and do not cause pressure against the blood vessels. Patients should be told to avoid walking barefoot or otherwise subjecting themselves to the hazards of trauma to the feet and legs. Should such an accident occur, no matter how minor it may seem, the patient must notify a health care provider so that treatment may be begun and infection and ulceration can be prevented.

throm·bo·an·gi·i·tis

(throm'bō-an'jē-ī'tis),
Inflammation of the intima of a blood vessel, with thrombosis.
[thrombo- + G. angeion, vessel, + -itis, inflammation]

thromboangiitis

/throm·bo·an·gi·itis/ (throm″bo-an″je-i´tis) inflammation of a blood vessel, with thrombosis.
thromboangiitis obli´terans  Buerger's disease; an inflammatory and obliterative disease of the blood vessels of the limbs, primarily the legs, leading to ischemia and gangrene.

thromboangiitis

[throm′bō·an′jē·ī′tis]
an inflammation of the blood vessels associated with thrombosis and accompanied by destruction of the intima.

throm·bo·an·gi·i·tis

(throm'bō-an'jē-ī'tis)
Inflammation of the intima of a blood vessel, with thrombosis.
[thrombo- + G. angeion, vessel, + -itis, inflammation]

thromboangiitis

inflammation of tunica intima, with local thrombosis formation

thromboangiitis

inflammation of a blood vessel, with thrombosis.
References in periodicals archive ?
Buerger's disease, also called thromboangiitis obliterans (TAO), is a recurrent vaso-occlusive disease.
There have been rare case reports of thromboangiitis obliterans in older male smokers involving the upper and lower extremities.
Other potential benefits are against osteoarthritis and such vascular diseases as thromboangiitis obliterans (Buerger's disease) and may be against arteriosclerosis--and as a possible alternative to angioplasty or heart bypass surgery.
Olin JW: Thromboangiitis obliterans (Buerger's Disease).
Pathologically, BFD is compatible with thromboangiitis obliterans and arteriosclerosis obliterans (12,13).
It develops and markets autologous bone marrow-derived progenitor cells as regenerative therapeutics for cardiovascular diseases focusing on ischemic heart disease (Acute Myocardial Infarction and Chronic Ischemic Heart Disease), and Thromboangiitis Obliterans, or Buerger's Disease.
The problems of smoking needs to be addressed as it leads not only to thromboangiitis obliterans and various cancers but also to pneumonia, cough and chronic obstructive airway disease.
26 August 2011 - Israeli Pluristem Therapeutics Inc (NASDAQ:PSTI) said on Thursday that on 22 August the US Food and Drug Administration (FDA) designated its PLX cells Orphan Drug status for the treatment of thromboangiitis obliterans (Buerger's disease).
Thromboangiitis obli terans (Buerger's disease) (Fig 3) is an obstructive vascular disease caused by segmental inflammatory and proliferative lesions of the tunica media of small arteries and weins.
The report titled 'India: Peripheral Arterial Disease, Thromboangiitis Obliterans and Critical Limb Ischemia Epidemiology and Markets' is the third in a series published on CLI.
INTRODUCTION: Thromboangiitis Obliterans (Buerger's disease) is a non-atherosclerotic segmental inflammatory disease that most commonly affects the small and medium-sized arteries, veins, and accompanying nerves of the arms and legs.
It was approved for the treatment of ischemic symptoms such as skin ulcer, pain and coldness accompanying thromboangiitis obliterans in 1988, and for the treatment of subjective symptoms such as pain and numbness of lower leg and walking disability associated with acquired lumbar spinal canal stenosis as an additional indication in 2001.