thromboangiitis


Also found in: Dictionary, Encyclopedia.
Related to thromboangiitis: Buerger's disease

thromboangiitis

 [throm″bo-an″je-i´tis]
inflammation of a blood vessel (vasculitis) with thrombosis.
thromboangiitis obli´terans a disease affecting the medium-sized blood vessels, particularly the arteries of the lower limbs, which can cause severe pain and in serious cases lead to gangrene. The name refers to the clotting, pain, and inflammation occurring in this disease and to the fact that it can obliterate, or destroy, blood vessels. The cause has been thought to be excessive use of tobacco over a long period of time, and the number of cases has diminished strikingly in recent years. The intense pain is caused by thrombosis (formation of blood clots) in the lining of the arteries; when the clots grow larger, the blood flow slows and may stop entirely. Since every part of the body depends on the continuous flow of blood, affected areas such as fingers and toes, for example, soon begin to atrophy or develop ulcers. If the causes of the disease are not completely arrested, amputation may be necessary.



To treat the disease, the patient must stop smoking at once and entirely. This generally results in the partial healing of the affected membrane with a renewed flow of blood. However, more blood may have to be brought to damaged tissue by surgical methods of channeling detours or making canals in the clot itself. Sympathectomy may be tried to prevent any vasospastic component. Minor amputations of gangrenous tissue are often needed.

Special exercises called buerger-allen exercises are sometimes used to empty the engorged blood vessels and stimulate collateral circulation. These exercises can be done at home by patients and are usually prescribed to be done several times during the day. Patients are also instructed to avoid wearing any tight clothing, such as tight girdles, rolled garters, constricting belts, and other items that may impair circulation. They should also avoid sitting or standing in one position for long periods of time. Care should be used in the selection of shoes and stockings so that they fit properly and do not cause pressure against the blood vessels. Patients should be told to avoid walking barefoot or otherwise subjecting themselves to the hazards of trauma to the feet and legs. Should such an accident occur, no matter how minor it may seem, the patient must notify a health care provider so that treatment may be begun and infection and ulceration can be prevented.

throm·bo·an·gi·i·tis

(throm'bō-an'jē-ī'tis),
Inflammation of the intima of a blood vessel, with thrombosis.
[thrombo- + G. angeion, vessel, + -itis, inflammation]

thromboangiitis

/throm·bo·an·gi·itis/ (throm″bo-an″je-i´tis) inflammation of a blood vessel, with thrombosis.
thromboangiitis obli´terans  Buerger's disease; an inflammatory and obliterative disease of the blood vessels of the limbs, primarily the legs, leading to ischemia and gangrene.

thromboangiitis

[throm′bō·an′jē·ī′tis]
an inflammation of the blood vessels associated with thrombosis and accompanied by destruction of the intima.

throm·bo·an·gi·i·tis

(throm'bō-an'jē-ī'tis)
Inflammation of the intima of a blood vessel, with thrombosis.
[thrombo- + G. angeion, vessel, + -itis, inflammation]

thromboangiitis

inflammation of tunica intima, with local thrombosis formation

thromboangiitis

inflammation of a blood vessel, with thrombosis.
References in periodicals archive ?
This orphan drug designation supports Stempeutics global development strategy for Stempeucel drug and the goal of providing improved therapies for patients with Thromboangiitis Obliterans.
We view this as an important milestone to further develop our novel stem cell biological drug Stempeucel in the EU for treating Thromboangiitis Obliterans indication.
The rise and fall and resurgence of thromboangiitis obliterans (Buerger's disease).
Autoimmune mechanisms in thromboangiitis obliterans (Buerger's disease): the role of tobacco antigen and the major histocompatibility complex.
Thromboangiitis obliterans of coronary and internal thoracic arteries in a young woman.
Stempeutics Research, a group company of Manipal Education and Medical Group and a Joint Venture with Cipla Group, announced today that the European Medicines Agency (EMA) has granted Advanced Therapy Medicinal Product classification for its novel stem cell drug ' Stempeucel ' which will be used for the treatment of Thromboangiitis Obliterans (TAO).
Stempeucel will be a blessing for European patients who have been suffering with the rare disease - Thromboangiitis Obliterans.
Research indicates an increasing prevalence (11%-23%) of thromboangiitis obliterans in women, although the prevalence in Japanese and other Asian women remains low despite increased smoking.
Farish SE, EI-Mofty SK, Cohn SJ: Intraoral manifestation of thromboangiitis obliterans (Buerger's disease).
O'Dell JR, Linder J, Markin RS, et al: Thromboangiitis obliterans (Buerger's disease) and smokeless tobacco.
Buerger's Disease, or thromboangiitis obliterans, affects about 50,000 patients in the United States and in Europe, respectively.
15% should be used with caution in patients with depression, cerebral or coronary insufficiency, Raynaud's phenomenon, orthostatic hypotension or thromboangiitis obliterans.