thrombin (redirected from thrombin-thrombomodulin complex)

thrombin /throm·bin/ (throm´bin)

1. the activated form of coagulation factor II (prothrombin); it catalyzes the conversion of fibrinogen to fibrin.

2. a preparation derived from prothrombin of bovine origin together with thromboplastin and calcium; used therapeutically as a local hemostatic.

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throm·bin (thrmbn)

n.

An enzyme in blood formed from prothrombin that facilitates blood clotting by reacting with fibrinogen to form fibrin. Also called thrombase.

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Thrombin

Thrombin is a protein produced by the body. It is a specific clotting factor that plays an important role in the blood clotting process.

Mentioned in: Anticoagulant and Antiplatelet Drugs, Fibrinogen Test, Prothrombin Time

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thrombin

[throm′bin]

an enzyme formed from prothrombin, calcium, and thromboplastin in plasma during the clotting process. Thrombin causes fibrinogen to change to fibrin, which is essential in the formation of a clot. Also called factor IIa. See also blood clot , prothrombin.

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thrombin (throm´bin),

n a proteolytic enzyme formed from prothrombin by the action of thromboplastin, factor IV calcium (Ca⁺⁺), and other factors. Thrombin forms fibrin from fibrinogen, speeds up the disruption of platelets, and activates factor V.

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thrombin

an enzyme resulting from activation of prothrombin, which catalyzes the conversion of fibrinogen to fibrin. It is also a potent stimulus to the aggregation of platelets. A preparation from prothrombin of bovine origin is used as a topical hemostatic.

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thrombin-thrombomodulin complex

thrombomodulin, a specific endothelial cell surface receptor, converts thrombin, a very weak activator of protein C in the anticoagulant pathway, to the status of a very active protein C activator.

thrombin time

the time required for a standardized solution of thrombin to clot plasma. It is a measure of the rate of conversion of fibrinogen to fibrin.

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thrombin

Hematology A key clot promoting enzyme that converts fibrinogen to fibrin and protects against fibrinolysis by activating thrombin-activatable fibrinolysis inhibitor. See Fibrin, Fibrinolysis, TAFI.