thrombin


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Related to thrombin: antithrombin, Thrombin time

thrombin

 [throm´bin]
1. the activated form of coagulation factor II (prothrombin), which catalyzes the conversion of fibrinogen to fibrin.
2. a preparation of this compound prepared from prothrombin of bovine origin, used as a topical hemostatic.
thrombin time (TT) the time required for plasma fibrinogen to form thrombin: exogenous thrombin is added to citrated plasma and the time to clot formation is measured. Prolonged TT is seen with abnormalities of fibrinogen and in the presence of heparin or degradation products of fibrin or fibrinogen.

throm·bin

(throm'bin),
1. An enzyme (proteinase), formed in shed blood, that converts fibrinogen into fibrin by hydrolyzing peptides (and amides and esters) of l-arginine; formed from prothrombin by the action of prothrombinase (factor Xa, another proteinase).
2. A sterile protein substance prepared from prothrombin of bovine origin through interaction with thromboplastin in the presence of calcium; causes clotting of whole blood, plasma, or a fibrinogen solution; used as a topical hemostatic for capillary bleeding with or without fibrin foam in general and plastic surgical procedures.

thrombin

/throm·bin/ (throm´bin)
1. the activated form of coagulation factor II (prothrombin); it catalyzes the conversion of fibrinogen to fibrin.
2. a preparation derived from prothrombin of bovine origin together with thromboplastin and calcium; used therapeutically as a local hemostatic.

thrombin

(thrŏm′bĭn)
n.
A protease in blood that facilitates blood clotting by converting fibrinogen to fibrin.

thrombin

[throm′bin]
the key enzyme produced during coagulation by activation of prothrombin. Thrombin converts fibrinogen to fibrin, activates factors V, VIII, XI, and XIII, and causes platelet aggregation. See also blood clot , prothrombin.

thrombin

Hematology A key clot promoting enzyme that converts fibrinogen to fibrin and protects against fibrinolysis by activating thrombin-activatable fibrinolysis inhibitor. See Fibrin, Fibrinolysis, TAFI.

throm·bin

(throm'bin)
1. An enzyme (proteinase), formed in shed blood, that converts fibrinogen into fibrin by hydrolyzing peptides (and amides and esters) of l-arginine; formed from prothrombin by the action of prothrombinase (factor Xa, another proteinase).
2. A sterile protein substance prepared from prothrombin of bovine origin through interaction with thromboplastin in the presence of calcium; causes clotting of whole blood, plasma, or a fibrinogen solution; used as a topical hemostatic for capillary bleeding with or without fibrin foam in general and plastic surgical procedures.
Synonym(s): factor IIa.

thrombin

An enzyme in the blood that converts fibrinogen to fibrin, thus forming a blood clot.

thrombin

see BLOOD CLOTTING.

Thrombin

Thrombin is a protein produced by the body. It is a specific clotting factor that plays an important role in the blood clotting process.

thrombin

clotting cascade enzyme, formed from prothrombin

throm·bin

(throm'bin)
1. An enzyme (proteinase), formed in shed blood, which converts fibrinogen into fibrin by hydrolyzing peptides (and amides and esters) of l-arginine; formed from prothrombin by the action of prothrombinase.
2. A sterile protein substance prepared from prothrombin of bovine origin through interaction with thromboplastin in the presence of calcium; causes clotting; used as a topical hemostatic for capillary bleeding in general and plastic surgical procedures.
Synonym(s): factor IIa.

thrombin (throm´bin),

n a proteolytic enzyme formed from prothrombin by the action of thromboplastin, factor IV calcium (Ca++), and other factors. Thrombin forms fibrin from fibrinogen, speeds up the disruption of platelets, and activates factor V.

thrombin

an enzyme resulting from activation of prothrombin, which catalyzes the conversion of fibrinogen to fibrin. It is also a potent stimulus to the aggregation of platelets. A preparation from prothrombin of bovine origin is used as a topical hemostatic.

thrombin-thrombomodulin complex
thrombomodulin, a specific endothelial cell surface receptor, converts thrombin, a very weak activator of protein C in the anticoagulant pathway, to the status of a very active protein C activator.
thrombin time
the time required for a standardized solution of thrombin to clot plasma. It is a measure of the rate of conversion of fibrinogen to fibrin.
References in periodicals archive ?
After discussion with the patient, family and the primary team, decision was made to treat the pseudoaneurysm with percutaneous thrombin injection.
In a second experiment the thrombin injection was applied 6 hours following treatment and 80% of the heparin treated mice died whereas all the animals with the HA-heparin mice survived.
Thrombin generation (resulting from the activation of the procoagulant factors) and decay (resulting from the inhibitory action mediated by the anticoagulant factors) are followed over time.
On the other hand, homocysteine (Hcy), an amino acid metabolized from methionine [11], enhances thrombin generation [12, 13].
Fibrin sealants (Tisseel, TachoSil) are made of thrombin and concentrated fibrinogen from human plasma.
5) The use of serum as a test specimen produced misleading results because of variable production of thrombin and Xa, with subsequent variable consumption of antithrombin.
Percutaneous thrombin injection is a simple, safe and effective technique for managing femoral pseudoaneurysms.
a) The bivalent include bivalirudin and lepirudin; bind both to the active site and Exosite 1 (E1) of thrombin.
Direct thrombin inhibitors (DTIs) are a class of anticoagulants that act by directly inhibiting thrombin to delay clotting and are typically used during HIT and in acute coronary syndrome (see Table 1).
The product is based on a mixture of fibrinogen and thrombin, two blood clotting proteins, and is a unique dry powder topical tissue sealant that is currently in development to stop bleeding after or during surgery.
To recall, ENVI's resolution against amendments aiming at allowing the use of thrombin as a food additive was approved last month on the grounds that its use is misleading for consumers and presents a risk of pathogenic bacteria infection.