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third generation cephalosporin

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third generation cephalosporin
Infectious disease A group of broad-spectrum antibiotics–eg, cefatoxime, ceftazidime, ceftriaxone and moxalactam that are structurally related to penicillins and used against penicillinase-producing bacteria; TGCs are more active against enteric bacteria, are stable against the β-lactamases of H influenzae and N gonorrhoeae, have a longer serum T1/2 than 1st generation cephalosporins– administered twice/day, cross the blood-brain barrier and effective against gram-negative CNS infections


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Super-Infection Many second and particularly third generation cephalosporins are ineffective against gram­positive organisms, especially stayphylococci and enterococci.
A 2 week course of oral doxycycline or amoxycillin for Stage I and a third generation cephalosporin for Stage II are the most commonly used regimens.
 
 
 
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