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thiouracil

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thi·o·u·ra·cil (th-yr-sl)
n.
A white crystalline compound that interferes with the synthesis of thyroxine, used to reduce thyroid gland activity, especially in the treatment of hyperthyroidism.
thiouracil
[thī′ōyoo͡r′əsil]
Etymology: Gk, theion, sulfur, ouron, urine
a chemical compound derived from thiourea that inhibits the formation of thyroxine in the thyroid gland and is used to treat hyperthyroidism.
thiouracil
a thyrotoxic agent that inhibits the oxidation of iodine thus preventing the formation of thyroxine. Used to treat hyperthyroidism, and has been used as a fattening agent in cattle.
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When relative efficacy was compared with that of propyl thiouracil (PTU), a standard antithyroidic drug, experimental seed extract appeared to be more effective.
Annona squamosa seed extract in the regulation of hyperthyroidism and ... by Panda, S.; Kar, A. / Phytomedicine: International Journal of Phytotherapy & Phytopharmacology
Similar thyroid hyperplasia has been observed after treatment of fish with goitrogens such as thiourea and thiouracil that inhibit coupling and formation of iodotyrosines in the thyroid.
Effects of ammonium perchlorate on thyroid function in developing ... by Brown, J. Anne / Environmental Health Perspectives
Because PBDEs have the ability to interfere with thyroid hormone (TH) homeostasis, we included a reference group for TH-mediated effects by adding the goitrogen 6-n-propyl thiouracil (PTU) in the drinking water of pregnant females.
Developmental exposure to low-dose PBDE-99: effects on male fertility ... by Chahoud, Ibrahim / Environmental Health Perspectives
 
 
 
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