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thiotepa

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thiotepa /thio·tepa/ (-tep´ah) a cytotoxic alkylating agent, used as an antineoplastic in the treatment of breast, ovarian, or bladder cancer, Hodgkin's disease, and malignant pleural or pericardial effusion.
thiotepa
[thī′ōtep′ə]
an antineoplastic alkylating agent.
indications It is prescribed in the treatment of malignant neoplastic diseases, including adenocarcinoma of the breast and ovary, and urinary bladder carcinomas.
contraindications Bone marrow depression, pregnancy, or known hypersensitivity to this drug prohibits its use. Dosage must be decreased if there is liver or kidney dysfunction.
adverse effects Among the most serious adverse effects are bone marrow depression, anorexia, nausea, and headache.

thiotepa [thi″o-te´pah]
a cytotoxic alkylating agent used as an antineoplastic agent in the treatment of cancer of the breast, ovary, or bladder, pericardial or pleural effusions secondary to malignancy, and Hodgkin's disease; used by intracavitary, intratumor, intravesical, or intravenous administration.

thiotepa
triethylenethiophosphoramide; a cytotoxic alkylating agent used as an antineoplastic agent.

thiotepa
Triethylenethiophosphoramide, Thioplex® Oncology A relatively toxic alkylating agent used topically to manage transitional cell cancer of the urinary bladder


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Suspect Drugs Chemotherapy Agents Associated With Neurotoxicity Combination of methotrexate*, cyclophosphamide, and fluorouracil* Vinca alkaloids Cytarabine Platinum analogues Ifosfamide Taxol Taxotere Fludarabine Suramin Agents Associated With Occasional Reports of Cognitive or Motor Impairment L-asparagine Busulfan Hexamethylmelamine Procarbazine Thiotepa *Also associated with cognitive impairment individually.
Subsequently, stem cells were given after the administration of carmustine and 3 months later after the administration of thiotepa.
 
 
 
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