thioridazine


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thioridazine

 [thi″o-rid´ah-zēn]
a phenothiazine used orally in the form of the base or the hydrochloride salt as an antipsychotic agent and sedative.

thioridazine

/thi·o·rid·a·zine/ (-rid´ah-zēn) a tranquilizer with antipsychotic and sedative effects, used as the base or hydrochloride salt.

thioridazine

(thī′ə-rĭd′ə-zēn′)
n.
A phenothiazine drug, C21H26N2S2, that is used in the form of its hydrochloride to treat psychotic disorders.

thioridazine

A typical piperidine antipsychotic used for short-term management of depression with anxiety. Thioridazine decreases excitement, hypermotility, affective tension, and agitation by psychomotor inhibition. High doses are discouraged, given the concerns relating to cardiotoxicity and retinopathy.
 
Adverse effects
Drowsiness, pseudoparkinsonism, extrapyramidal symptoms, nocturnal confusion, hyperactivity, lethargy, psychotic reactions, restlessness, headache, dry mouth, blurred vision, constipation, nausea, vomiting, diarrhoea, nasal congestion, galactorrhoea, breast engorgement, amenorrhoea, ejaculation inhibition, peripheral oedema.

thioridazine

Mellaril® Pharmacology A chlorpromazine-like antipsychotic, metabolized to the therapeutically active mesoridazine

thioridazine

An antipsychotic drug used to treat SCHIZOPHRENIA and MANIA. A brand name is Melleril.

thioridazine

a phenothiazine tranquilizer used in the treatment of stereotypic and aggressive behavior in dogs.
References in periodicals archive ?
Acute dystonic reactions was noted by the exposure of atypical antipsychotics risperidone, olanzapine, and the typical antipsychotic thioridazine in our study.
3) Table 2 Effects of Paroxetine on Other Drugs Concomitant Drug Name Effect of Paroxetine on Other Drugs Thioridazine Increased plasma concentrations of thioridazine Potential QTc prolongation Pimozide Increased plasma concentrations of pimozide.
Unwanted effects related to thioridazine rises earlier when compared to the other phenothiazines.
Thioridazine is known to inhibit dopamine receptors.
Bhatia's team also found that thioridazine works through the dopamine receptor on the surface of the cancer cells in both leukemia and breast cancer patients.
Researchers are planning a clinical trial of thioridazine in combination with standard anti-cancer drugs for adults with acute myeloid leukaemia.
They are also targeted by thioridazine in the brain, where they play a role in schizophrenia.
14] previously reported that sertraline and thioridazine administration potentiated protein levels in the brain, liver and heart of rabbits, but had no effect on brain monoamine oxidase activity.
Furthermore, several drugs may produce false positive results for phencyclidine including ketamine, dextromethorphan, diphenhydramine, ibuprofen, imipramine, meperidine, mesoridazine, thioridazine, and venlafaxine (Sena, Kazimi & Wu 2002).
We saw this when a "black box" warning was published on thioridazine.
Effects of thioridazine (Mellaril) on titrating delayed matching-to-sample performance of mentally retarded adults.
Tableau 1 Principales donnees demographiques des sujets Sexe n Hommes 19 Femmes 2 Origine ethnique Caucasienne 19 Hispanique 1 Afro-americaine 1 Substances consommees (abus ou dependance) au cours des 3 derniers mois Alcool 8 Amphetamine 1 Cannabis 13 Cocaine 6 PCP 1 Medication concomitante Antidepresseurs 7 Anticholinergiques 1 Anticonvulsivants 1 Benzodiazepines 2 Stabilisateurs de l'humeur 3 Antipsychotiques recus anterieurement Chlorpromazine 1 Fluphenazine 1 Haloperidol 3 Olanzapine 10 Risperidone 6 Thioridazine 1 Ziprasidone 1 Zuclopenthixol 1 Autres variables Moyenne [+ o -] D.