thioguanine


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thioguanine

 [thi″o-gwah´nēn]
a guanine analogue in which sulfur replaces the oxygen atom of guanine; used as an antineoplastic agent almost exclusively in the treatment of acute myelogenous leukemia and acute lymphoblastic leukemia. Called also 6-thioguanine and 6-TG.

thioguanine

/thio·gua·nine/ (-gwah´nēn) an antineoplastic derived from mercaptopurine; used in the treatment of acute myelogenous leukemia.

thioguanine

[thī′ōgwä′nēn]
a purine analog antagonist, an antineoplastic that acts as an antimetabolite.
indications It is prescribed in the treatment of a variety of malignant neoplastic diseases, especially acute and chronic myelogenous leukemias.
contraindications Known hypersensitivity or resistance to this drug prohibits its use. It is not given during pregnancy.
adverse effects Among the most serious adverse effects are bone marrow depression, GI distress, and stomatitis.

thioguanine

Lanvis® Oncology An antimitotic purine analogue, used against AML. See Purine.

thioguanine

Tioguanine, a drug used in the treatment of acute myeloblastic leukaemia. A brand name is Lanvis.

thioguanine

an antineoplastic (2-aminopurine-6-thiol) used in the treatment of leukemia.
References in periodicals archive ?
Kinetics of mercaptopurine and thioguanine nucleotides in renal transplant recipients during azathioprine treatment.
MPNs predominated over thioguanine and MeMPN concentrations at 6 h, but at 20 h, MPN concentrations were lower and MeMPN concentrations were higher relative to concentrations at 6 h.
Methylation of mercaptopurine, thioguanine, and their nucleotide metabolites by heterologously expressed human thiopurine S-methyltransferase.
High-performance liquid chromatographic assay of the methyl and nucleotide metabolites of 6 mercaptopurine: quantification of red blood cell 6 thioguanine nucleotide, 6 thioinosinic acid and methylmercaptopurine metabolites in a single sample.
A reversed phase high performance liquid chromatographic approach in determining total red blood cell concentrations of 6 thioguanine, 6 mercaptopurine, methylthioguanine and methylmercaptopurine in a patient receiving thiopurine therapy.
To this end, intracellular thioguanine nucleotides (TGN) serve as the most informative measure of systemic exposure.
leukocytes, lymphoblasts), these thioguanine nucleotides are incorporated into DNA and RNA-which is considered an important mechanism of cytotoxicity.