4% lower with NA statin + OCP BMI, body mass index; NA, not available; OCP, oral contraceptive pill; PCOS, polycystic ovary syndrome; RCT, randomized controlled trial; TZD, thiazolidinedione
Reasonable combinations of drugs include a sulfonylurea plus metformin, a sulfonylurea plus an -glucosidase inhibitor, a sulfonylurea plus a thiazolidinedione
, metformin plus repaglinide, biguanide plus [alpha]-glucosidase inhibitor, and metformin plus a thiazolidinedione
(Lin and Sun 2010).
At least two thiazolidinediones
rosiglitazone and pioglitazone--are available in lower-dose formulations in combination with metformin, and the combinations provide the same level of diabetes control as do higher-dose glitazone monotherapy, he said.
Although troglitazone is now off the market due to its hepatotoxicity, other thiazolidinediones
that activate PPAR[gamma] are currently used as antidiabetic agents.
Fehmida Visnegarwala and colleagues plan to study rosiglitazone (Avandia), which belongs to a new class of drugs called thiazolidinediones
, in the context of lipodystrophy.
SAN FRANCISCO--Adults who started taking suLfonylurea drugs for diabetes were 9% more likely to develop fractures within 5 years, and patients starting thiazolidinediones
were 9% more likely to have fractures, compared with patients on other medications in a retrospective study of 99,892 adults.
The guidance covers a therapy combination with metformin, sulphonylureas and thiazolidinediones
, which are currently used to address Type 2 diabetes by lowering the glucose levels in the blood.
Washington, May 4 (ANI): A new study has warned that drugs known as thiazolidinediones
, or TZDs for short, which are widely used in diabetes treatment, have a large downside.
Patients taking sulfonylureas, sitagliptin, or thiazolidinediones
showed less improvement from baseline than did patients taking the injectables.
, such as rosiglitazone, can decrease the rate of progression to diabetes (SOR: B, randomized controlled trial [RCT]), they pose a significant risk of fluid overload and heart failure.