diuretics cause massive degenerative changes and cell death in the distal tubule in rats (16).
diuretics act in the cortical collecting duct and thus impair urinary diluting capacity, but maintain concentrating ability, whereas loop diuretics, which act in the thick ascending limb of Henle, impair both urinary diluting and concentrating capacity.
Exposure to [beta]-blockers and thiazide
-like diuretics prior to the index date was noted for both groups (JAMA 2004;292:1326-32).
diuretics, beta blockers, angiotensin-converting enzyme inhibitors, and alpha blockers are less effective in some patients who use NSAIDs.
Each patient received one to three of these drugs: a sulfonylurea, a thiazide
, loop diuretic, a carbonic anhydrase inhibitor, a triptan, celecoxib, amprenavir, or dapsone (a sulfone).
Hydrochlorothiazide is a thiazide
diuretic used in the management of hypertension either alone or to enhance the effect of other antihypertensive drugs in the more severe forms of hypertension.
Lithium Interaction Lithium generally should not be given with thiazides
Combining low-dose thiazide
diuretics with most classes of antihypertensive agents increases efficacy and adds little toxicity.
The following drugs may decrease the effectiveness of insulin, resulting in hyperglycemia: acetazolamide, albuterol, asparaginase, calcitonin, corticosteroids, cyclophosphamide, danazol, dextrothyroxine, diazoxide, diltiazem, diuretics, dobutamine, epinephrine, estrogens, ethacrynic acid, HIV antivirals, isoniazid, lithium, morphine, niacin, oral contraceptives, phenothiazines, phenytoin, somatropin, terbutaline, thiazide
diuretics, and thyroid supplements.
Goals were met by 67% of patients taking a beta-blocker plus diuretic, by 65% of those taking a thiazide
or thiazidelike diuretic, by 57% of those taking an ACE inhibitor plus hydrochlorothiazide, by 54% of those taking a calcium channel blocker, by 51% of patients taking an angiotensin receptor blocker plus hydrochlorothiazide, by 46% of those on ACE inhibitor monotherapy, and by 45% of those prescribed an angiotensin receptor blocker alone.
Calcium channel blockers, corticosteroids, estrogens, isoniazid, nicotinic acid, oral contraceptives, phenothiazines, phenytoin, sympathomimetics, thiazide
diuretics, and thyroid supplements may cause hyperglycemia in combination with other antidiabetic agents, so blood glucose levels should be closely monitored when one of these drugs is added or discontinued.
Evaluate 24-hour urinary calcium secretion and add calcium, vitamin D, or thiazide