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thiamine hydrochloride(thi'a-men?) [? + ?]
It acts as a coenzyme of carboxylases in the decarboxylation of pyruvic acid and is therefore essential for the liberation of energy and the transfer of pyruvic acid into the Krebs cycle.
Symptoms may include fatigue, muscle tenderness and increased irritability, disturbances of extraocular movement, loss of appetite, or cardiovascular disturbances. Alcoholics are especially prone to develop thiamine deficiency. Prolonged severe deficiency (e.g., during starvation) results in beriberi.