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therapeutic ratio

   Also found in: Dictionary/thesaurus, Wikipedia 0.01 sec.
therapeutic ratio
n.
The ratio of the maximally tolerated dose of a drug to the minimally curative or effective dose.


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13) To overcome the issue of inadequate dose, the radiation oncologist must attempt to increase the therapeutic ratio to avoid normal tissue complications while increasing the dose to the tumor and, ultimately, increasing local control (Figure 6).
The drug has a very narrow therapeutic ratio, with neurotoxicity and nephrotoxicity being the limiting factors.
We conclude that interferon alpha-2b possesses greater therapeutic activity in vitro than ribavirin, with a potentially greater therapeutic ratio in humans.
 
 
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