This condition developed rapidly, within weeks of initiation of treatment, and required intervention with therapeutic phlebotomy
He was adherent to a therapeutic phlebotomy
schedule to control iron overload.
Life-saving diagnostic and therapeutic phlebotomy should never be denied or delayed for lack of liver biopsy in patients with laboratory indicators of iron overload.
Initiation of therapeutic phlebotomy is based on serum ferritin and does not require liver biopsy
Treatment has centered on cytoreduction by therapeutic phlebotomy and/or treatment with cytoreductive pharmaceuticals such as hydroxyurea or [alpha]-interferon.
Treatment for PV includes therapeutic phlebotomy with the goal of maintaining the hematocrit at below 45% in males and below 40% in females.
Mundis determined that the patient needed a therapeutic phlebotomy
, a procedure similar to blood donation, in order to reduce the thickness of her blood.
Because this step applies only to hematocrits above 55% the target hematocrit for performing a therapeutic phlebotomy
was also analyzed.
First, given the fact that this patient has not undergone any therapeutic phlebotomy
for several years, it is possible that this patient's iron stores are abnormally increased, despite her low normal ferritin concentration.
Hemochromatosis Patient Renal Patient Cause of overload Increased iron Multiple transfusions absorption or parenteral iron therapy, decreased iron incorporation into the erythroid marrow Where iron Liver, spleen, heart Mostly the accumulates reticuloendothelial system Treatment Therapeutic phlebotomy
Withholding parenteral iron, administering EPO, chelation
Blood Bank: Autologous Blood-Derived Products for Chronic Non-Healing Wounds; Blood transfusions; autologous, allogeneic, donor directed; Cord blood storage; Granulocyte and Platelet Transfusions; Plasmapheresis, plasma exchange, apheresis and related procedures; Lipid apheresis; Nonselective (random) transfusions and living-related donor specific transfusions in kidney transplantation; Therapeutic Phlebotomy
At the same time, Aethlon will discontinue its focus on the Hemopurifier as a primary treatment of hereditary hemochromatosis due to the uncertainty of demonstrating a long-term clinical and economic improvement over standard therapeutic phlebotomy
, which is becoming a no-cost procedure under recently revised FDA guidelines.