therapeutic immune paralysis

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Chemical 'splenectomy' A method that inhibits splenic endocytosis of opsonized–ie, Ig- or complement-coated cells or microorganisms by blocking Fc receptors; the targets are thus bound, but not endocytosed; TIP is inducible by high-dose–corticosteroids or IVIG; the effect lasts as long as the therapy and is an alternative to surgery in immune-related hypersplenism–eg, autoimmune hemolytic anemia, autoimmune neutropenia, Felty syndrome

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