thapsigargin


Also found in: Wikipedia.

thapsigargin

(thap-si-gar'jin),
a highly potent and selective inhibitor of sarcoendoplasmic reticulum family of Ca2+-ATPases used in research on intracellular calcium stores.
[Thopsia garganica, plant source + -in]
References in periodicals archive ?
mansoni ATP diphosphohydrolases inhibitors, cardamonin presents better results for ATPase activity compared to other compounds described in literature, such as thapsigargin (Martins et al.
Mipsagargin consists of a thapsigargin derivative, 12ADT, coupled to a peptide that helps solubilize the prodrug and prevents its internalization into cells until the peptide is removed.
In DrugTissueCult we focus on two bioactive compounds Thapsigargin and Withaferin A with anticancer properties.
Overexpression of regucalcin suppresses cell death in cloned rat hepatoma h4-ii-e cells induced by tumor necrosis factor-alpha or thapsigargin.
Ten nM thapsigargin (a SERCA inhibitor), 1 [micro]M atropine (a muscarinic receptor blocker) and 100 [micro]M L-NAME (a NO synthase inhibitor) and 500 uM DECC were used to investigate the mechanisms of DECC action.
Unlike typical chemotherapeutic agents, thapsigargin kills cells irrespective of the rate of cell division, which may provide an effective approach to kill both fast- and slow-growing cancers as well as cancer stem cells.
Thapsigargin (TG, 586005), tunicamycin (TUN, 654380), and brefeldin A (BFA, 203729) were purchased from EMD Chemicals Inc.
Samuel Denmeade at Johns Hopkins University in Baltimore, Maryland, and colleagues have spent 15 years engineering an analogue of thapsigargin, the plant's active ingredient, which works by shutting down essential calcium pumps inside cells.
The plant makes a product, dubbed thapsigargin that since the time of ancient Greece has been known to be toxic to animals.
The plant makes a product, dubbed thapsigargin, that since the time of ancient Greece has been known to be toxic to animals.
The effects persisted under an extracellular Ca2+-free condition but were abolished by intracellular BAPTA and pretreatment with thapsigargin.
The Sarcoplasmic Reticulum Ca2+ Pump: Inhibition by Thapsigargin and Enhancement by Adenovirus-mediated Gene Transfer.