Ogino, Comparison of Contractions Produced by Carbachol, Thapsigargin
and Cyclopiazonic Acid in the Guinea-Pig Tracheal Muscle, J.
Chemistry Briefs presents some fascinating stories, including how thapsigargin
, a molecule extracted from the poisonous Mediterranean plant Thapsia garganica, has become a powerful weapon in the oncologist's arsenal.
This milestone signifies the advancement in Phyton's Plant Cell Fermentation (PCF) development program that now has begun to define the process by which the Thapsia plant is converted into a preserved, fermentable cell line, thus providing a more sustainable source of high-quality thapsigargin
ATF6 as a transcription activator of the endoplasmic reticulum stress element: thapsigargin
stress-induced changes and synergistic interactions with NF-Y and YY1.
2+]-ATPase inhibitor thapsigargin
(TG), glucocorticoids, and various cancer therapeutic drugs, and early transient elevation of intracellular free calcium ([[Ca.
2+] spark properties and rescued the arrhythmogenic phenotype CPTV Flecainide and Thapsigargin
blocked ads-beta blockers improved [Ca.
(100 nM, Sigma) and pravastatin (10 [micro]M, Squibb) were used as the agonist and antagonist for ER stress .
Oligodendrocytes were cultured in the presence of Thapsigargin
(TG) (#T9033, Sigma-Aldrich, USA) 1 [micro]mol/L for ERS induction.
In DrugTissueCult we focus on two bioactive compounds Thapsigargin
and Withaferin A with anticancer properties.
Heparin coated PMMA IOL,  thapsigargin
(endoplasmic reticulum based Ca-ATPase inhibitor) coated IOL  and indomethacin coated IOL  have been attempted.
Overexpression of regucalcin suppresses cell death in cloned rat hepatoma h4-ii-e cells induced by tumor necrosis factor-alpha or thapsigargin
Ten nM thapsigargin
(a SERCA inhibitor), 1 [micro]M atropine (a muscarinic receptor blocker) and 100 [micro]M L-NAME (a NO synthase inhibitor) and 500 uM DECC were used to investigate the mechanisms of DECC action.