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tetrahydrobiopterin

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tetrahydrobiopterin
[tet′rə·hī′drō·bī·op′tər·in]
a compound related to folic acid that functions as a coenzyme in the reactions hydroxylating phenylalanine, tryptophan, and tyrosine by carrying electrons to oxygen. Defects in its biosynthesis or regeneration affect all three hydroxylation reactions, interfere with production of the corresponding neurotransmitter precursors, and result in malignant hyperphenylalaninemia.
tetrahydrobiopterin
pterin cofactor in the mixed-function oxygenase, phenylalanine hydroxylase which catalyzes the conversion of phenylalanine to tyrosine. Hereditary deficiency of this enzyme is responsible for phenylketonuria (PKU).
tetrahydrobiopterin
Metabolic disease A natural cofactor of aromatic amino acid hydroxylases and nitric oxide synthase, which may be used as an alternative to low-phenylalanine diets in Pts with mild phenylketonuria. See Phenylketonuria.
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63) By administering only alpha tocopherol as was done in the flawed study, one would expect gamma tocopherol to be suppressed, peroxynitrite levels to increase, and precious tetrahydrobiopterin to be oxidized, thus depriving the endothelium of the nitric oxide it needs to protect against heart attack and stroke.
Dietary supplements under attack by Faloon, William / Life Extension
Folates are alleged to participate in the endogenous regeneration of tetrahydrobiopterin (Wever et al.
Possible relationship of folic acid supplementation and improved ... by Hoch, Anne Z.; Pajewski, Nicholas M.; Hoffmann, Raymond G.; Schimke, Jane E.; Gutterman, David D. / Journal of Sports Science and Medicine
Nitric oxide synthase catalyzes the reaction which converts L-arginine to citrulline and NO and requires help of calmodulin and pteridin tetrahydrobiopterin (BH4)as cofactors.
Nitric oxide and cardiovascular system/Nitrik oksit ve ... by Cengel, Atiye; Sahinarslan, Asife / The Anatolian Journal of Cardiology (Anadolu Kardiyoloji Dergisi)
 
 
 
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