cosyntropin

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cosyntropin

 [ko″sin-tro´pin]
a synthetic corticotropin used in the screening of adrenal insufficiency on the basis of plasma cortisol response after intramuscular or intravenous injection.

co·syn·tro·pin

(kō-sin-trō'pin),
α1-24- or β1-24-Corticotropin; a synthetic corticotrophic agent, comprising the first 24 amino acyl residues of human ACTH, which sequence is found in several other species and which retains the full biologic activity of the complete ACTH; the remaining 15 residues differ among species and confer specific immunologic properties.

cosyntropin

/co·syn·tro·pin/ (ko-sin-tro´pin) a synthetic polypeptide identical with a portion of corticotropin, having its corticotropic activity but not its allergenicity; used in the screening of adrenal insufficiency on the basis of plasma cortisol response.

cosyntropin

(kō′sĭn-trō′pĭn)
n.
A synthetic corticotropin.

cosyntropin

[kō`sintrop′in]
a synthetic form of adrenocorticotropic hormone that is used in the diagnosis and treatment of adrenal hypofunction disorders such as Addison's disease to determine if the disorder is primary (adrenal dysfunction) or secondary (hypothalamic-pituitary axis dysfunction).

cosyntropin

a synthetic corticotropin used in the screening of adrenal functional capacity on the basis of plasma cortisol response after intramuscular or intravenous injection. Called also tetracosactrin.
References in periodicals archive ?
The tender number includes the following medicines: Tender no: 1, Atc code: H01aa02, Generic name: Tetracosactide, Dispensing form: Injection, Strength: 0.
Addition of the ACTH analog tetracosactide caused an 8-fold increase in corticosterone secretion.
Tetracosactide (Synacthen Depot, 1 mg/mL) was obtained from Ciba (V.
The synthetic ACTH analog tetracosactide was added (11 nM) to stimulate ACTH-regulated enzyme activity in the slices.
Adrenal slices exposed to tetracosactide maintained a constant rate of [sup.
Tetracosactide exposure for 24 hr increased corticosterone content in the medium 8-fold (p [is less than] 0.
Exposure of slices to both metyrapone and tetracosactide for 24 hr produced no significant decrease in corticosterone secretion, compared with slices exposed to tetracosactide only.
2]-DDE (50 [micro]M) and tetracosactide showed a reduction in the rate of corticosterone secretion (90%) at time points exceeding 6 hr of incubation, compared with slices exposed to tetracosactide where the rate of corticosterone secretion remained constant for 30 hr of incubation (Figure 3).
14]C]DDE and tetracosactide were characterized by a marked labeling of zona fasciculata (Figure 4 A,B).
Since tetracosactide stimulates both CYP11A1 and CYP11B1 activity (22,24,32-35), this peptide would be expected to increase both corticosterone synthesis and irreversible Me[SO.