tetherin


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tetherin

A 29–33-kD type-II transmembrane glycoprotein encoded by BST2 on chromosome 19p131, which is expressed on some synovial cells, bone marrow stem cell lines, and type-I IFN-producing cells. It may be involved in sorting secreted proteins, and in pre-B-cell growth. It is an antiretroviral defense protein, blocking the release of enveloped virus from the cell surface. It is active against retroviruses, filoviruses, arenaviruses, and herpesviruses; is depleted upon HIV-1 infection by viral VPU protein via 20S proteasome degradation, and on infection by HHV-8 by ubiquitination and degradation. It may play a role in B-cell activation in rheumatoid arthritis.
 
Normal expression
Tetherin/BST2 is up-regulated on most cell types after stimulation with type-I IFNs and IFN-gamma, and is highly expressed on terminally differentiated dendritic cells.
 
Abnormal expression
Myeloma, renal cell carcinoma, melanoma cells.
References in periodicals archive ?
In the case of HIV, a protein called Vpu counteracts tetherin.
He said that there is some possibility that tetherin exists in different forms that might explain differences among people in the progression of HIV or other viral infections.
However, the only common variation they've seen in the tetherin gene so far does not appear to affect its function.
However, the current study has revealed that the Ebola virus has developed a way to disable tetherin, thus blocking the body's response and allowing the virus to spread.
This information gives us a new way to study how tetherin works.
Studies conducted in the past have shown that tetherin plays a role in the immune system's response to HIV-1, a retrovirus, and that it is also disabled by HIV.