tetanus toxoid

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a toxin treated by heat or chemical agent to destroy its deleterious properties without destroying its ability to combine with or stimulate the formation of antitoxin.
diphtheria toxoid a sterile preparation of formaldehyde-treated products of the growth of Corynebacterium diphtheriae, used as an active immunizing agent, generally in mixtures with tetanus toxoid and pertussis vaccine (DTP) or with tetanus toxoid alone (DT for pediatric use and Td, which contains less diphtheria toxoid, for adult use).
tetanus toxoid a sterile preparation of formaldehyde-treated products of the growth of Clostridium tetani, used as an active immunizing agent, either in mixtures with diphtheria toxoid and pertussis vaccine (DTP, DT, Td) or by itself (T).

tetanus toxoid

an active immunizing agent prepared from detoxified tetanus toxin that produces an antigenic response in the body, conferring permanent immunity to tetanus infection.
indications It is prescribed for primary active immunization against tetanus, generally in combination with diphtheria and pertussis vaccines.
contraindications Immunosuppression or immunoglobulin abnormalities, acute infection, or illness prohibits its use.
adverse effects The most serious adverse effect is hypersensitivity. Pain and inflammation at the site of injection may occur.

tetanus toxoid

 A small peptide fragment that selectively elicits helper immune response but not immune suppression

Tetanus toxoid

Tetanus toxoid is a vaccine used to prevent tetanus (also known as lockjaw).
Mentioned in: Clenched Fist Injury

tetanus toxoid (tetˑ·ns täkˑ·soid),

n detoxified tetanus poison used to produce a permanent immune response against tetanus infections. See also tetanus vaccine.


a highly fatal disease of all animal species caused by the neurotoxin of Clostridium tetani. The bacterial spores are deposited in tissue, usually by traumatic injury, retained placenta or endometrial injury and under anaerobic conditions vegetate. Clinical features of the disease are remarkably similar in all species but there are differences in susceptibility to the disease. The muscle spasms cause a stiff gait, rigid posture (sometimes called 'sawhorse stance'), extension or elevation of the tail, protrusion of the third eyelid and trismus (lockjaw). Horses show flaring of the nostrils. In dogs, spasms of facial muscles cause abnormally erect ears and retraction of the lips that resembles the 'risus sardonicus' seen in humans with tetanus. Stimulation precipitates generalized muscle contractions and tetanic spasms or convulsions. The disease can be prevented by immunization with tetanus toxoid or the use of antitoxin, but this is done routinely only in humans and horses.

tetanus antitoxin
see tetanus antitoxin.
idiopathic tetanus
a loosely defined syndrome of outbreaks of tetanus in young cattle without a wound being found; current practice is to refer to such outbreaks as being caused by the ingestion of pre-formed tetanus toxin.
localized tetanus
tetany occurs predominantly in one limb, closest to the site of entry of the organism, but then usually spreads to the opposite limb and then the whole body. Seen in dogs and particularly cats.
tetanus toxin
see tetanus toxin.
tetanus toxoid
see toxoid.
References in periodicals archive ?
As a result, they commissioned laboratory testing that found beta HCG in the tetanus toxoid vaccine, despite conflicting assurances from Ministry of Health, they said.
Bhattacharya N, "A Study on the Intraamniotic Instillation of Tetanus Toxoid on A Growing Human Fetus", Dissertation submitted to the Calcutta University (India), for the degree of Doctor of Science( D.
Booster doses of Td at doses of 1 Lf and 5 Lf of tetanus toxoid induced tetanus antitoxin levels greater than 0.
Still, in our previous study, a doubling of the PCB exposure at 18 months was associated with a decrease in the concomitant antibody response to the diphtheria toxoid by 24%, and the decrease in the tetanus toxoid antibody at age 7 years was 16% for each doubling of the prenatal exposure level (Heilmann et al.
Secondary end points included a twofold increase in tetanus toxoid titer; a twofold increase or an increase of more than one mcg/mL from prevaccination levels in immune response to the PPV23; post-vaccination KLH titers; and postvacci-nation DTH reactions, based on a C.
Only if one is known to be significantly sensitive to diphtheria toxoid should tetanus toxoid alone be used.
They identified the compound in each step by measuring the ability of various fractions to inhibit the proliferation of immune cells stimulated with tetanus toxoid.
South Central Regional Medical Center in Laurel, MS asked for ice and tetanus toxoid doses.
The series of activities during the week includes public awareness activities at village supplemented by immunization and de worming for children, tetanus toxoid vaccination for pregnant mothers, refresher trainings for health workers, and strengthened public health systems to ensure that Oral Rehydration Salts (ORS) and other essential supplies are available and correctly used.
Pregnant women receiving two tetanus toxoid shots increased from 48% at baseline to 56% at endline.
In June 2005, a vaccine containing acellular pertussis antigens, tetanus toxoid, and reduced diphtheria toxoid (Tdap) was licensed for use in persons aged 11-64 years.