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testolactone

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testolactone
[tes′təlak′tōn]
an antineoplastic androgen analog.
indications It is prescribed as palliative treatment of advanced postmenopausal breast cancer and in premenopausal women whose ovarian function has been terminated.
contraindications Pregnancy, lactation, or known hypersensitivity to this drug prohibits its use. It is not given to men.
adverse effects Among the more serious adverse effects are hypercalcemia and peripheral neuropathies with numbness or tingling.


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16) Antiestrogen drugs such as tamoxifen and testolactone have been used in selected cases with success.
Aggressive fibromatosis of the parapharyngeal space: two cases and ... by Nathan, Cherie-Ann O. / Ear, Nose and Throat Journal
Wang and Swerdloff (11) reported that the administration of testosterone with the aromatase inhibitor testolactone prevented gonadotropin inhibition by testosterone, which suggests that a component of this inhibitory feedback mechanism is related to the conversion of testosterone to estrogen by aromatase.
Aromatase inhibition for the treatment of idiopathic hypogonadotropic ... by Cohen, Paul G. / Southern Medical Journal
 
 
 
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