terminal deoxynucleotidyl transferase


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terminal deoxynucleotidyl transferase (TdT),

a specialized DNA polymerase expressed in immature, pre-B, pre-T lymphoid cells, and acute lymphoblastic leukemia/lymphoma cells.

ter·mi·nal de·ox·y·nu·cle·o·ti·dyl trans·fer·ase

(TdT) (tĕr'mi-năl dē-oks'ē-nū-klē-ō-tī'dil trans'fĕr-ās)
A specialized DNA polymerase expressed in immature, pre-B, pre-T lymphoid cells, and acute lymphoblastic leukemia/lymphoma cells.
References in periodicals archive ?
Cell death was detected using the Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay at various capsaicin concentrations and exposure times.
In our case, terminal deoxynucleotidyl transferase, CD34, myeloperoxidase, CD68, CD163, muramidase, and CD45 were negative within the large cell population, assisting in ruling out a CD4+ leukemia cutis.
In a study by Kallkury, flow cytometric analysis revealed 1% to 20% precursor B cells based on expression of 1 or more pan B cell antigens in addition to CD10, CD34 and terminal deoxynucleotidyl transferase (TDT) 11.
T-cell lymphoblasts variably express early and pan T-cell antigens and terminal deoxynucleotidyl transferase.
OncoVista's lead product candidate is Cordycepin (OVI-123), which is in Phase I/II clinical trials for refractory leukemia patients who express the enzyme terminal deoxynucleotidyl transferase (TdT).
Using terminal deoxynucleotidyl transferase mediated dUTP nick end labeling (TUNEL) and flow cytometric analysis, APS-1d was found to induce apoptosis and also tended to induce S phase arrest in HeLa cells.
Immunohistochemical staining for either terminal deoxynucleotidyl transferase (TdT) or CD99 was done when the patient had AML, and myeloperoxidase (MPO) was stained if the patient had ALL.
The fixed cells were washed twice with wash buffer included in the kit, and freshly prepared DNA labeling solution [containing terminal deoxynucleotidyl transferase and 5-bromo-2'-deoxyuridine (BrdU) 5'-triphosphate] was added to the cell pellet and incubated overnight at room temperature.
The NTPs, digoxigenin-11-2'-dUTP (Dig-dUTP), yeast tRNA, blocking reagent, the anti-Digalkaline phosphatase conjugate and terminal deoxynucleotidyl transferase were from Boehringer Mannheim.
The neoplastic cells of lymphoblastic lymphoma are usually positive for terminal deoxynucleotidyl transferase.
Comparison of two methods of staining apoptotic cells of leukemia cell lines: terminal deoxynucleotidyl transferase and DNA polymerase I reactions.
We stained tissue sections with terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end labeling (TUNEL) to identify apoptotic bodies.

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