terfenadine


Also found in: Dictionary, Wikipedia.
Related to terfenadine: Astemizole

terfenadine

A non-sedating antihistamine used for allergies and viral upper respiratory tract infections. It is available in Canada, the UK, and in some other countries by prescription, but was withdrawn from US market due to cardiotoxicity.

Adverse effects
Arrhythmias (e.g., torsades de pointes, which may be due to delayed repolarisation with marked QT prolongation) and bizarre T-wave changes.

terfenadine

Seldane® A non-sedating antihistamine used for allergy and viral URIs Adverse effects Arrhythmias–eg, torsades de pointes; should not be combined with ketoconazole, an antifungal that alters its metabolism, resulting in accumulation of the parent compound, a K+ channel blocker that prolongs QT. See Allegra.

terfenadine

A non-sedating antihistamine drug used to treat ALLERGIC RHINITIS and URTICARIA. The drug can cause heart irregularities and should not be used by people with heart or liver disease. It should not be taken with grapefruit juice which increases its bioavailability.

terfenadine (terfen´ədēn´),

n brand name: Seldane;
drug class: antihistamine;
action: acts on blood vessels and gastrointestinal and respiratory systems by competing with histamine for peripheral H1 receptor sites; decreases allergic response by blocking histamine;
uses: rhinitis, allergy symptoms.

terfenadine

a nonsedating antihistamine used in the treatment of allergies.
References in periodicals archive ?
Norvir should not be taken with the following medicines: astemizole, terfenadine, amiodarone, bepridil, encainide, flecainide, propafenone, quinidine, dihydroergotamine, ergotamine, ergonovine, methylergonovine, clorazepate, diazepam, estazolam, flurazepam, triazolam or oral (taken by mouth) midazolam, clozapine, pimozide, pethidine, piroxicam, propoxyphene, cisapride rifabutin, voriconazole, simvastatin, lovastatin, alfuzosin, fusidic acid, sildenafil used to treat a lung disease called pulmonary arterial hypertension, and products containing St John's wort (Hypericum perforatum).
Control of nausea and autonomic dysfunction with terfenadine, a peripherally acting antihistamine.
As an example, when the nonsedating antihistamine terfenadine was commercially available, certain "azole" antifungal agents had the potential to increase concentrations of terfenadine by inhibiting its metabolism thus increasing the prevalence of terfenadine side effects (eg, QT prolongation).
He even suggests warnings on the grocery counters where grapefruit and grapefruit juice are sold (the need for this may be less urgent since terfenadine has been withdrawn).
Warfarin, phenytoin (anti-epileptic) and terfenadine (antihistamine) - decreases the effectiveness of these drugs when taken with thrush tablets containing fluconazole, such as Diflucan One.
It has decided that because of a handful of cases where some sufferers have had a bad reaction, the vast majority of hay fever sufferers cannot buy relieringing drugs like Terfenadine and Astemizole over the counter.
Read the label - some contain Terfenadine, which may cause disorders in heart rhythm if taken in combination with antiobiotics such as erthromycin, with anti-fungals or with grapefruit juice.
Terfenadine is sold under brand names including Triludan, Triludan Forte, Seldane, Terfenor, Aller-Eze Clear, and Boots Antihistamine Tablets.
With the arrival of a new drug, fexofenadine, a derivative of terfenadine (the generic name for Seldane), the FDA is now proposing to remove its approval of Seldane and take it off the market.
The company has 30 days in which to request a hearing on why terfenadine, the generic name of Seldane, should not be taken off the market.
One of the drugs is terfenadine (trade name Seldane), which doctors prescribe to clear up congestion.
INVIRASE/ritonavir should not be administered concurrently with terfenadine, cisapride, astemizole, pimozide, triazolam, midazolam or ergot derivatives.