terfenadine


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Related to terfenadine: Astemizole

terfenadine

A non-sedating antihistamine used for allergies and viral upper respiratory tract infections. It is available in Canada, the UK, and in some other countries by prescription, but was withdrawn from US market due to cardiotoxicity.

Adverse effects
Arrhythmias (e.g., torsades de pointes, which may be due to delayed repolarisation with marked QT prolongation) and bizarre T-wave changes.

terfenadine

Seldane® A non-sedating antihistamine used for allergy and viral URIs Adverse effects Arrhythmias–eg, torsades de pointes; should not be combined with ketoconazole, an antifungal that alters its metabolism, resulting in accumulation of the parent compound, a K+ channel blocker that prolongs QT. See Allegra.

terfenadine

A non-sedating antihistamine drug used to treat ALLERGIC RHINITIS and URTICARIA. The drug can cause heart irregularities and should not be used by people with heart or liver disease. It should not be taken with grapefruit juice which increases its bioavailability.

terfenadine (terfen´ədēn´),

n brand name: Seldane;
drug class: antihistamine;
action: acts on blood vessels and gastrointestinal and respiratory systems by competing with histamine for peripheral H1 receptor sites; decreases allergic response by blocking histamine;
uses: rhinitis, allergy symptoms.

terfenadine

a nonsedating antihistamine used in the treatment of allergies.
References in periodicals archive ?
Effect of concomitant administration of cimetidine and ranitidine on the pharmacokinetics and electrocardiographic effects of terfenadine.
Selective inhibitors of CYP2J2 related to terfenadine exhibit strong activity against human cancers in vitro and in vivo.
Terfenadine was the first "no drowsiness" antihistamine, introduced in the 1980s.
Bunlar, sisaprid (gastrointestinal motilite kolaylastirici), oral midazolam(benzodiazepin turevi bir sedatif, hipnotik, anestezide kullanilabilir), pimozid (antipsikotik), kinidin, dofetilid (antiaritmik), triazolam(sedatif benzodiyazepin), terfenadine ve astemizol (antihistaminikler), simvastatin, ve lovastatindir (kan yaglarini dusurucu statinler).
A double-blind, single-dose, crossover comparison of cetirizine, ebastine, epinastine, fexofenadine, terfenadine, and loratadine versus placebo: Suppression of histamineinduced wheal and flare response for 24 h in healthy male subjects.
Further, metabolites identified during clinical trials may exhibit desirable side effects which can be exploited to yield another active drug-the nonsedating antihistamine terfenadine was shown to be metabolized to another nonsedating antihistamine, fexofenadine, having a better safety profile and now marketed as Allegra[R].
Sam Frost, "The Unique Problem of Inventions Which Are Fully Enabled and Fully Described, but Not Fully Understood (Merrell Dow's Terfenadine Revisited)" (2007) 20 I.
For example, terfenadine was withdrawn from the American market in 1998 following unsuccessful attempts to limit its administration together with other arrhythmogenic agents (49).
Failure of terfenadine in relieving the pruritus of atopic dermatitis.
The use of nonsedating antihistamines, eg, terfenadine and astemizole, from 1985 to 1999 provided an important case study of the public health issues with widespread use of noncardiac drugs that have cardiac effects.
Coadministration is contraindicated for ergot alkaloids, terfenadine, astemizole, cisapride, pimozide, halofantrine, and quinidine.
Special Considerations: Emend is a weak to moderate CYP3A4 inhibitor, so it should not be used with pimozide, terfenadine, astemizole, or cisapride.