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terfenadine

   Also found in: Wikipedia 0.01 sec.
terfenadine (terfen´dēn´),
n brand name: Seldane;
drug class: antihistamine;
action: acts on blood vessels and gastrointestinal and respiratory systems by competing with histamine for peripheral H1 receptor sites; decreases allergic response by blocking histamine;
uses: rhinitis, allergy symptoms.

terfenadine
a nonsedating antihistamine used in the treatment of allergies.

terfenadine
Seldane® A non-sedating antihistamine used for allergy and viral URIs Adverse effects Arrhythmias–eg, torsades de pointes; should not be combined with ketoconazole, an antifungal that alters its metabolism, resulting in accumulation of the parent compound, a K+ channel blocker that prolongs QT. See Allegra.


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For example, terfenadine was withdrawn from the American market in 1998 following unsuccessful attempts to limit its administration together with other arrhythmogenic agents (49).
Terfenadine and astemizole may increase the risk of abnormal heart rhythms.
The use of nonsedating antihistamines, eg, terfenadine and astemizole, from 1985 to 1999 provided an important case study of the public health issues with widespread use of noncardiac drugs that have cardiac effects.
 
 
 
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