terbutaline sulfate

terbutaline sulfate

Monovent

Pharmacologic class: Selective beta2-adrenergic receptor agonist

Therapeutic class: Bronchodilator

Pregnancy risk category B

Action

Relaxes bronchial smooth muscle by stimulating beta2-adrenergic receptors; inhibits release of hypersensitivity mediators, especially from mast cells

Availability

Injection: 1 mg/ml

Tablets: 2.5 mg, 5 mg

Indications and dosages

Bronchospasm in reversible obstructive airway disease

Adults and children older than age 12: 0.25 mg subcutaneously, repeated in 15 to 30 minutes p.r.n., up to a maximum of 0.5 mg in 4 hours. Or 2.5 to 5 mg P.O. q 6 hours t.i.d. while awake, up to a maximum of 15 mg/day in adults; 2.5 mg P.O. q 6 hours t.i.d. while awake, up to a maximum of 7.5 mg/day in children.

Dosage adjustment

• Renal impairment

Off-label uses

• Tocolytic in preterm labor

Contraindications

• Hypersensitivity to drug, its components, or sympathomimetic amines

Precautions

Use cautiously in:
• cardiovascular disorders, hypertension, arrhythmias, hyperthyroidism, diabetes mellitus, seizure disorders, glaucoma
• concurrent use of MAO inhibitors, tricyclic antidepressants, or beta-adrenergic blockers
• elderly patients
• breastfeeding patients.

Administration

• Inject subcutaneously into lateral deltoid.

Adverse reactions

CNS: tremors, anxiety, nervousness, insomnia, headache, dizziness, drowsiness, stimulation

CV: palpitations, chest discomfort, tachycardia

GI: nausea, vomiting

Skin: diaphoresis, flushing

Interactions

Drug-drug. Beta-adrenergic blockers: blockage of bronchodilating effect

MAO inhibitors, tricyclic antidepressants: potentiation of terbutaline's adverse cardiovascular reactions

Other sympathomimetic amines: additive adverse cardiovascular reactions

Patient monitoring

• Monitor vital signs.
• Assess neurologic status.

Patient teaching

• Tell patient he may take with or without food.
• Advise patient or parents to establish effective bedtime routine to minimize insomnia.
• Instruct patient or parents to space doses evenly during waking hours, to avoid taking drug at bedtime.
• As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs mentioned above.

terbutaline sulfate

[terbyo̅o̅′təlēn]
a beta2-adrenergic stimulant.
indications It is prescribed as a bronchodilator in the treatment of asthma, bronchitis, and emphysema and as a uterine relaxant to treat premature labor.
contraindications Cardiac arrhythmias or known hypersensitivity to this drug prohibits its use. Toxicity is increased by monoamine oxidase inhibitors and tricyclic antidepressants, and beta-adrenergic blocker effects are decreased.
adverse effects Among the most serious effects are dizziness and palpitations. Nervousness and tremor are common reactions.

Bricanyl

A beta-adrenergic receptor agonist used for patients with COPD.
 
Indications
Asthma, bronchitis, reversible bronchospasm.
 
Adverse effects
Tremor, nervousness, palpitations, nausea, vomiting.

terbutaline sulfate (terbū´təlēn´),

n brand names: Brethaire, Brethine, Bricanyl;
drug class: selective β2-agonist;
action: relaxes bronchial smooth muscle by direct action on β2-adrenergic receptors;
uses: bronchospasm, asthma prophylaxis, premature labor inhibitor.
References in periodicals archive ?
Different analytical techniques have been developed for determination of terbutaline sulfate and tetracycline including HPLC [89] LCMS [10] CE [11] CEMS [12] and voltammetry [13].
100 bots ciprofloxacin 200mg 100 vials dextrose 50% 50cc 50 amps diphenhydramine 100 bots dopamine premixed 120 vials hydrocortisone 250mg 20 amps terbutaline sulfate
APP) has received Food and Drug Administration approval for terbutaline sulfate injection, USP.
Terbutaline sulfate was prescribed, and the patient was discharged home.
Women pregnant with twins shouldn't be given a month's supply of terbutaline sulfate (Brethine) and told to take one when they have contractions, because there is no evidence that this prolongs pregnancy At least five studies show that prolonged use of oral tocolytics, including terbutaline and nifedipine (Procardia), is of no benefit for prolonging pregnancy in women with signs of preterm labor, said Dr.
I was given the drug, terbutaline sulfate (both orally and by injection), as well as betamethasone injections from my 24th week of pregnancy until his birth.
The pump is used with 3-mL syringes (3 mg of terbutaline sulfate per 3 mL).
Previous research has suggested that terbutaline sulfate increases serum glucose in pregnant women.
Food and Drug Administration (FDA) for the Abbreviated New Drug Application (ANDA) of Terbutaline Sulfate Tablets 2.
1,2] The clinical efficacy, flexibility of dosage required, ease of an administration, and relatively low cost have led to widespread use of terbutaline sulfate for tocolysis.
Food and Drug Administration has granted final approval for the Company's ANDA for Terbutaline Sulfate Injection, 1 mg/mL.