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Related to teratogens: thalidomide

teratogens, (tərat´ōjens),

n.pl agents that cause congenital malformations and developmental abnormalities if introduced during gestation.
References in periodicals archive ?
11,28] Several theories have been postulated to explain these observations and include the suggestion that the process of neurulation may occur at slightly different times in the development of male and female embryos, thereby accounting for differing susceptibilities to the effects of factors such as teratogens.
Many of these children display a range of cognitive and behavioural disorders (Welch-Carre 2005), which has led to alcohol being regarded as a behavioural teratogen and a leading cause of mental retardation in the Western world (Dunty 2001).
He also established the California Teratogen Information Service in 1979 to provide information to pregnant women and physicians about the potential teratogenic risk of drugs, chemicals and environmental agents to the developing fetus and to gain new information about their effects.
1994), established that FETAX could be used to detect teratogens in mammals.
The thalidomide tragedy and the rubella epidemic not only readied the public to understand the potential ramifications of alcohol abuse in pregnancy, these very public encounters with teratogens helped pave the way for the legalization of abortion as a "therapeutic option.
The courts focused on the statistical reanalysis, but the plaintiffs also wanted to introduce test tube and animal studies and information about other known teratogens whose chemical structure was said to be similar to Bendectin's.
and eight known or suspected teratogens (chemicals capable of producing birth defects in developing fetuses).
This embryonic alkalinity could lead to an accumulation of acids -- and it is known that human teratogens, at least, are in general weak acids.
Membranes which are high in cholesterol (including monosaturated and saturated fatty acids) are less fluid and more rigid allowing the passage of many damaging compounds such as carcinogens (cancer causing agents) and teratogens (that can cause genetic damage) through the membrane into the cell.
This is important: With only two exceptions, all known human teratogens also are teratogenic in animals.
Researchers in a number of disciplines in addition to development and toxicology contribute to discussions of such matters as signal transduction pathways as targets for teratogens, personalized nutrition and medicine in perinatal development, zebrafish as a non-mammalian model of developmental toxicology, integrating whole-animal developmental toxicity data into risk assessment, genomic approaches, and investigating drug effects in human pregnancy.
Taken in sum, the data from these studies provide increasingly convincing evidence that NSAIDs are human teratogens, especially for cardiac septal defects and, possibly, for orofacial clefts.