Understanding the mechanism of drug teratogenicity
could educate and also provide a foundation for prevention of fetal malformations in epileptic and non-epileptic women who are taking this drug during pregnancy25.
With this knowledge, the present study was conducted to evaluate the anti-angiogenicity and teratogenicity
Genotoxicity and Teratogenicity
of African Medicinal Plants; Kuete V.
of retinoic acid and its effects on TGF-beta2 expression in the developing cerebral cortex of the rat.
Embryoprotective efficacy of Rosmarinus officinalis (Rosemary) extract against developmental toxicity and teratogenicity
of mercuric chloride in the chick.
The chicken and mice embryos are best models for teratogenicity
studies (George and Mclone, 1995).
Under the prior rule, sponsors were required to notify FDA and all participating investigators within 15 calendar days of serious and unexpected adverse experiences associated with the use of the drug and any findings from tests in laboratory animals suggesting a significant risk for humans subjects (including mutagenicity, teratogenicity
, studies claim that the same agent applied at different stages of development produces different types of defects.
Requirements on an ideal in vitro teratogenicity
test system are stated, and the advantages and disadvantages of the present methods are discussed.
The two major side effects of concern are the risk of teratogenicity
and psychiatric changes, including depression.
details from health study findings on teratogenicity
, developmental toxicity, carcinogenicity, immunotoxicity, renal toxicity, hepatoxicity, pulmonary toxicity, and neurotoxicity;
Noven expects that the product label will contain similar warnings to those described in the Depakote product label, including those relating to life threatening adverse reactions concerning hepatotoxicity, teratogenicity
, and pancreatitis.