Alcohol has been a major teratogenic agent
However, the sensitivity of a certain in vitro test to a teratogenic agent
may depend on the underlying mechanism of action of the compound.
The Reference Centre for Teratogenic Agents
(Paris, France) and the manufacturer of bedaquiline approved giving this regimen because the fetus did not have major side effects.
Though the etiology may be unknown yet there may be the role of certain teratogenic agents
or angiogenic cell clusters (Differentiated from visceral mesoderm of the wall of the yolk sac] at the beginning of 3rd week of intrauterine life.
like cadmium ele ments, lead, vitamin A, cocaine and irradiation exposure are also reported to be associated with mermaid syndrome15-17 The new reproductive technology such as ICSI (Intra Cytoplasmic sperm injection) has also some association with mermaid syndrome.
Multi-factorial etiology has been reported for congenital carpal flexural deformities like teratogenic agents
, intrauterine mal-positioning and maternal diseases during pregnancy etc.
These findings could be caused by chromosome abnormalities, single gene mutations, or teratogenic agents
There are several teratogenic agents
and factors during pregnancy associated with formation of CLP, such as cortisone, anticonvulsants, salicylate, vitamin A, aminopterin, busalfan, organic solvents, maternal smoking, maternal hypoxia, maternal rubella, maternal diabetes mellitus, hypobaric hypoxia, and low social economical status.
There was no maternal history of ingestion of teratogenic agents
or diabetes mellitus.
The goal remains to produce a thorough reference linking studies of experimental teratogenic agents
to congenital defects in humans, and as such the volume will be of use to researchers in pharmaceuticals as well as obstetricians, pediatricians, and geneticists.
The factors that may interfere with the renal development are teratogenic agents
, genetic factors, chromosomal anomalies, disorders in the fusion mechanism of the ureteric bud and the metanephrogenic blastema, medicines ingested by the mother .
Many teratogenic agents
were also found to cause neurological and other functional disorders in children that are not necessarily associated with gross structural alterations.