teratogen


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teratogen

 [ter´ah-to-jen]
an agent or influence that causes physical defects in the developing embryo; called also developmental toxicant. adj., adj teratogen´ic.

ter·a·to·gen

(ter'ă-tō-jen),
Any agent (for example, a drug) or factor that induces or increases incidence of abnormal prenatal development.
[terato- + G. -gen, producing]

teratogen

/ter·a·to·gen/ (ter´ah-to-jen) any agent or factor that induces or increases the incidence of abnormal prenatal development.teratogen´ic

teratogen

(tə-răt′ə-jən, tĕr′ə-tə-)
n.
An agent, such as a virus, a drug, or radiation, that causes malformation of an embryo or fetus.

teratogen

[ter′ətəjen′]
Etymology: Gk, teras + genein, to produce
any substance, agent, or process that interferes with normal prenatal development, causing the formation of one or more developmental abnormalities in the fetus. Teratogens act directly on the developing organism or indirectly, affecting such supplemental structures as the placenta or some maternal system. The type and extent of the defect are determined by the specific kind of teratogen, its mode of action, the embryonic process affected, genetic predisposition, and the stage of development at the time the exposure occurred. The period of highest vulnerability in the developing embryo is from about the third through the twelfth week of gestation, when differentiation of the major organs and systems occurs. Susceptibility to teratogenic influence decreases rapidly in the later periods of development, which are characterized by growth and elaboration. Among the known teratogens are chemical agents, including such drugs as thalidomide, alkylating agents, and alcohol; infectious agents, especially the rubella virus and cytomegalovirus; ionizing radiation, particularly x-rays; and environmental factors, such as the age and general health of the mother or any intrauterine trauma that may affect the fetus, especially during the later stages of pregnancy. Also called teratogenic agent. Compare mutagen. teratogenic, adj.

teratogen

Genetics Any agent, chemical, or factor that causes a physical defect in a developing embryo or fetus; maternal medications with known teratogenic effects include aminopterin–spontaneous abortion, malformations; anticoagulants; anticonvulsants; cytotoxic drugs; mepivacaine–bradycardia, death; methimazole & propylthiouracil-goiter; 131I–destruction of fetal thyroid; ♂ sex hormones–methyltestosterone, 17-α-ethinyl-testosterone, 17-α-ethinyl-19-nortestosterone–causes masculinization of ♀, tetracycline–hypoplasia and pigmentation of tooth enamel; trimethadione–abortion, multiple malformations, mental retardation; ♀ sex hormones cause virilization with defective external genitalia, transplacental carcinogenesis by DES. See Fetal warfarin syndrome, Fetal hydantoin syndrome, Thalidomide. Cf Litogen.

ter·a·to·gen

(ter'ă-tō-jen)
A drug or other agent that can produce congenital anomalies or birth defects or increase the incidence of an anomaly in the population.
[terato- + G. -gen, producing]

teratogen

Any agent capable of causing a severe congenital bodily anomaly (monstrosity).

teratogen

a substance which increases the incidence of congenital malformations.

Teratogen

Any substance, agent, or process that interferes with normal prenatal development, causing the formation of one or more developmental abnormalities of the fetus.

teratogen

; teratogenic agent causing abnormal fetal development

teratogen (t·raˑ·t·gn),

n a process, a substance, or an agent that interferes with regular, thus causing developmental abnormalities within a fetus. Examples include alkylating agents, thalidomide, and alcohol; infectious microbes like cytome-galovirus or the rubella virus; ionizing radiation such as x-rays; and environmental aspects such as the mother's age and overall health or trauma to the fetus during the gestational period.

ter·a·to·gen

(ter'ă-tō-jen)
Any substance that induces incidence of abnormal prenatal development.
[terato- + G. -gen, producing]

teratogen

an agent or influence that causes physical defects in the developing embryo.
References in periodicals archive ?
Due to this geometric restriction, it was possible for the researchers to study the effect of teratogens, which may alter the shape and even the eventual position of the mesoendoderm layer.
In this study, a small proportion of the mothers had diabetes or they were epileptics on therapy; however, a further study with a larger sample would be required to analyse the impact of various known teratogens on the NTDs in this population.
However, the question as to what minimal change in a developmental parameter would display the presence of a potential teratogen is still challenging.
more than five standard drinks on one occasion (Kvigne 2003), at a point where embryonic or fetal development is particularly vulnerable to teratogens, may also be at risk of giving birth to an alcohol effected child.
With this in mind, meclizine could very well be considered a potential human teratogen.
Studies of alcohol as a teratogen in other species are reviewed in Carrie L.
In 2014, a teratogen information service in the United Kingdom reported on eight first-trimester exposures to oseltamivir and 37 to zanamivir, with no major birth defects noted in either group (BJOG.
In some states pharmacists can offer an oral hormonal contraceptive to women who are prescribed a teratogen and at risk for becoming pregnant.
Kenneth Lyons Jones, MD, professor in the UCSD Department of Pediatrics and a renowned expert in birth defects, and Christina Chambers, MPH, PhD, director of the California Teratogen Information Service (CTIS) Pregnancy Health Information Line claimed that these studies are misleading to pregnant women, citing more than 30 years of research to the contrary.
Alitretinoin is a potent teratogen, like other retinoids, but its relatively short half-life of 2-10 hours means that women of childbearing potential must continue on contraception for 1 month posttreatment, compared with 3 years for acitretin.
EMS is a byproduct of the manufacturing process and a known animal carcinogen, mutagen, and teratogen.
The study, conducted by researchers from California Teratogen Information Service (CTIS) Pregnancy Health Information Line, uses data obtained by counsellors at the CTIS Pregnancy Health Information Line, a toll-free service offering evidence-based clinical information about exposures during pregnancy and breastfeeding.