Lactic acidosis and hepatomegaly with steatosis, including fatal cases, have been reported with the use of nucleoside analogues including lamivudine and tenofovir
The patient was discharged on prednisolone and tenofovir
As a new antiviral drug for CHB, tenofovir
disoproxil (TDF) has recently been recommended as the first line of anti-HBV NAs medication by domestic and international CHB prevention and treatment guidelines.
Compared to formulations containing tenofovir
disoproxil fumarate, the newer tenofovir
alafenamide formulation achieves higher intracellular levels in CD4 lymphocytes (but not in renal tubular cells).
use has been associated with reduced bone mineral density and increases in biomarkers associated with bone metabolism, which may lead to an increase in fracture risk.
While several guidelines recommend excluding kidney disease before starting tenofovir
, and monitoring kidney function while on treatment so that tenofovir
can be stopped should toxicity develop, some authors argue that tenofovir
can be used safely without monitoring.
TAF is a novel targeted prodrug of tenofovir
that has demonstrated high antiviral efficacy similar to and at a dose less than one-tenth that of Gilead's Viread (tenofovir
disoproxil fumarate, TDF).
The pill, called Genvoya, includes doses of elvitegravir, cobicistat, emtricitabine and tenofovir
alafenamide and is meant especially for patients over age 12 who weigh at least 77 pounds and have not previously been treated for HIV.
Several randomized trials have found pre-exposure prophylaxis with oral or topical tenofovir
to be effective in reducing the risk of HIV acquisition, though none of them focused on women of reproductive age.
If you have a patient who's got diabetic nephropathy, a little proteinuria, and occasionally some glucosuria (4) because of intermittently uncontrolled diabetes, that might be a patient whose monitoring is going to be challenging, although their risk of tenofovir
toxicity is not increased.
is the only topical prophylactic shown to be effective at reducing the sexual transmission of HIV when formulated in a gel.
Some research has just been published where experts from Thailand and America have shown for the first time that an anti-AIDS drug, tenofovir
, can help prevent HIV in injecting drug users.