tenascin-C


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TNC

A gene on chromosome 9q32-q34 that encodes an extracellular matrix protein with a spatially and temporally restricted tissue distribution. It plays a role in guiding migrating neurons, as well as axons, during development, synaptic plasticity, and neuronal regeneration.

tenascin-C

(tĕn-ă′sĭn)
A glycoprotein found in the extracellular matrix that influences embryological development, tissue remodeling, and angiogenesis in infectious, inflammatory, and malignant diseases.
References in periodicals archive ?
Myofibroblastic stromal reaction and expression of tenascin-C and laminin in prostate adenocarcinoma.
Tenascin-C, tenascin-R, and tenascin-X: a family of talented proteins in search of their functions.
Potential oncogenic action of tenascin-C in tumorigenesis.
Tenascin-C levels were measured by commercially available kits based on enzyme-linked immunosorbent assay (ELISA) methods (Cusabio Biotech, Human Tenascin-C ELISA kit, Cat no: CSB-E13125h, Hubei Province, PR.
Tenascin-C plays a significant role in tissue remodeling, and increased TnC expression has been found to be associated with the initiation of fibrosis in the early process of tissue repair.
Tenascin-C has been believed to play a role in the immunologic system or in the pathogenesis of inflammatory diseases.
Although this paper marks a real breakthrough, medical science is no stranger to tenascin-C.
We therefore hypothesized that tenascin-C in the bone marrow might be helping to direct the activity of stem-cell-like endothelial progenitor cells," explained lead researcher Dr.
However, in studies conducted both in mice and in heart attack patients, the Weill Cornell team discovered that tenascin-C also reappears in and around the heart to help guide clot-induced neovascularization.
This SBIR grant will enable Acorda and the UMDNJ team to further explore the potential therapeutic uses of tenascin-C fragments in such conditions.
They add that high levels of tenascin-C present in joints, therefore, may cause the activated immune system to attack the joint leading to the persistent inflammation of rheumatoid arthritis.
The team hope that scientists can develop new treatments that target the interaction between tenascin-C and TLR4, which may help to combat rheumatoid arthritis.