These regulatory events have implications for various target molecules, including BRCA1, Tenascin
C, and PTEN, that are involved in both signaling pathways and cell migration.
generating a transcriptional profile from the first and second human skin samples of a set of genes consisting of fibrillin 1 (FBNl), fibulin 1 (FBLNl), tenascin
XB (TNXB), fibronectin 1 (FNl), lysyl oxidase homolog 2 (LOXL2), collagen, type I, alpha 1 (COLlAl), collagen, type III, alpha 1 (COL3Al), elastin (ELN) and Iysyl oxidase-like 1 (LOXLl);
expression and postnatal development of the human prostate.
Interestingly, we still found several skin stem cell markers expressed at lower levels in regenerating velvet, including integrin alpha 6/CD49f, CD200, follistatin, tenascin
, YAP1, and the general stem cell marker, CD34 (Blanpain and Fuchs, 2006).
Immunohistochemical expression of extracellular matrix components tenascin
, fibronectin, collagen type IV and laminin in breast cancer: their prognostic value and role in tumour invasion and progression," European Journal of Cancer, vol.
The variables responsible for membrane strengthening remain unknown while upregu lation of the matrix-related protein tenascin
C (Mackey et al.
Airway inflammation and basement membrane tenascin
in newly diagnosed atopic and nonatopic asthma.
Carcinoma cells have the ability to transform fibroblasts into reactive myofibroblasts, which synthesize different ECM components: collagen, fibronectin, tenascin
, versican, galectin, laminin and others.
This analysis revealed three top-ranking pathways, which are listed in their respective order: complement and coagulation cascades (14 downregulated genes in the H group), systemic lupus erythematosus (14/16 downregulated genes in the H group) and ECM -receptor interactions (7 downregulated genes, including collagen, type IV, alpha 6 (COL4A6), tenascin
C (TNC), secreted phosphoprotein 1 (SPP1), collagen, type I, alpha 2 (COL1A2), COL1A1, CD44 molecule (CD44), and ribosomal protein L26 (RPL26), and 5 upregulated genes, including integrin, beta 6 (ITGB6), syndecan 4 (SDC4), agrin (AGRN), thrombospondin 4 (THBS4), BT.
Those markers include HMGA1 and 2, CD163, ApoD, tenascin
, S100A6, MMP2 and 11, IGFBP7, cathepsin K, and D2-40.
Evidence for the evolution of tenascin
and fibronectin early in the chordate lineage.
Collagen (type I, III, and V on the airway wall and type IV and VIII under the basement membrane) and elastin account for approximately 2/3 of the dry weight of ECM, while the remainder is made up of glycoproteins (fibronectin, tenascin
, laminin) and other matrix components (heparin sulfate, hyaluronan).