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temsirolimus

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temsirolimus,
a biologic response modifier.
indication This drug is used to treat renal cell carcinoma.
contraindications Breastfeeding, pregnancy, and known hypersensitivity to this drug, sirolimus, or polysorbate 80 prohibit its use.
adverse effects Adverse effects of this drug include seizures, hypertension, hypertriglyceridemia, hyperlipidemia, hyperglycemia, nausea, vomiting, diarrhea, constipation, pruritus, and metabolic acidosis. Life-threatening side effects include thrombophlebitis, bowel perforation, albuminuria, hematuria, proteinuria, renal failure, anemia, leukopenia, thrombocytopenia, interstitial lung disease, and lymphoma. Common side effects include headache and rash.


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In in vitro studies using renal cancer cell lines, temsirolimus inhibited the activity of mTOR and resulted in reduced levels of the hypoxia-inducible factors HIF-1 and HIF-2 alpha, and the vascular endothelial growth factor.
The National Institute for Health and Clinical Excellence (Nice) yesterday rejected arguments over the use of bevacizumab (Avastin), sorafenib (Nexavar) and temsirolimus (Torisel) as first treatment options for advanced kidney cancer or cancer that has spread around the body.
I stress that this interim arrangement applies only to bevacizumab (Avastin), sorafenib (Nexavar), sunitinib (Sutent) and temsirolimus (Torisel) currently being reviewed by Nice for use in advanced renal cancer.
 
 
 
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