Type I collagen is the most abundant protein component of bone, and C- and N-terminal telopeptides
of type I collagen (CTX and NTX) are both fragments of type I collagen from the telopeptide
region, a nontriple-helical portion near the ends of mature collagen (Fig.
Patients on fluoxetine also had the lowest levels of C-terminal cross-linked telopeptide
of type 1 collagen (CTX), a biochemical marker of bone turnover, said Dr.
Objective: This study aimed to evaluate the expressions and clinical significance of bone Gla-protein (BGP) bone alkaline phosphatase (B-ALP) and C-terminal telopeptide
of type I collagen (CTX) in patients with osteoporosis (OP) and to provide evidence for developing individualized treatment plans.
The investigators also examined a molecular biomarker of cartilage tissue degradation: the urinary level of C-terminal cross-linking telopeptide
of type II collagen, which correlates with radiographic progression of OA.
, the amino terminal cross-linked peptide of type I collagen is released during bone resorption and has been correlated with BMD T-Score (11)
By 2 months after ovariectomy, telopeptide
concentrations were significantly reduced by etidronate (p < 0.
1-8) In these investigations, markers, such as osteocalcin, deoxypiridinoline, telopeptide
of type I collagen, and procollagen, were assayed before and after treatment with anti-TNF-alpha in patients with inflammatory conditions.
Bone alkaline phosphatase (bAP) and aminoterminal propeptide of procollagen I (PNIP) in serum and urinary a-isomer of the carboxy-terminal telopeptide
of collagen I (a-CTX) were measured.
One amino acid is within the helical region; the other two are within the telopeptide
region of the two collagen molecules.
Seattle, WA; 206-292-8082), Osteometer Biotech A/S (Herlev, Denmark), Diagnostic Systems Laboratories (Houston, TX), and the Washington Research Foundation (Seattle, WA), announced that they have entered into an agreement settling a lawsuit brought against Osteometer and DSL for infringement of patents exclusively licensed by the Foundation to Ostex and directed to C-terminal telopeptide
markers of bone resorption.
Bone turnover markers including osteocalcin and C-terminale telopeptide
were in normal range [osteocalcin: 58.
Serum C-terminal cross-linking telopeptide
level was maintained in the denosumab arm and increased with ZA over 12 months.