References in periodicals archive ?
Comparison of telomerase assays using TRAP/PCR, TRAP/real-time PCR, and hTERT mRNA/RT-PCR.
One study found that telomerase appears to be even more accurate than examining cells under the microscope, now the standard way of judging whether they are cancerous.
Controlled activation of the enzyme telomerase may restore the regenerative and functional capacity of cells in various organ systems impacted by senescence, injury or chronic disease.
Although telomerase was discovered in 1985, exactly how this enzyme repairs telomeres to enable cancer cells to divide and grow was largely unknown.
Andrews, founder of Sierra Sciences, LLC and one of the principal discoverers of the telomerase genes, said: "Cleopatra, Ponce de Leon, and untold others throughout the ages have searched for the secrets of youth.
16 [micro]g of primer], incubated at 30 [degrees]C for 30 min, and then heated to 90 [degrees]C for 3 min to inactivate the telomerase activity.
Keynote Presentation: Targeting Telomerase for Cancer Therapeutics
It is believed that telomerase activity is required in essentially all tumours for the immortalisation of a subset of cells, including cancer stem cells.
When telomerase isn't active, each time our cells divide, the telomeres get shorter.
In most tissues, telomerase turns off during development, after which telomeres shorten and limit the number of times a cell can divide, eventually losing their capping function--similar to the shoelace tip falling off.
Telomerase protects the ends of chromosomes from being lost in the process of cell division and, thus, prevents that the cell ages and dies.
But in some, stem cells and cancer cells for example, telomeres are replenished through the action of telomerase, an enzyme that has both protein and ribonucleic acid, or RNA, components.