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tegafur

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tegafur
Uftoral® Oncology An antimetabolite prodrug absorbed from the small intestine and metabolized in vivo to 5-FU. See 5-FU, Prodrug.


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An example of activation is seen with the conversion of Tegafur into the active anticancer agent 5-fluorouracil (5-FU).
In another proof of principle, Hurel scientists tested the anticancer drug Tegafur using an animal-on-a-chip setup, says Baxter.
While most frequently reported in association with doxorubicin, cytarabine, docetaxel and fluorouracil, (20) HFS has been reported with multiple other agents including capecitabine, (21,22) vinorelbine (23,24) and the oral fluoropyrimidine TS-1 that is a combination of tegafur and uracil.
 
 
 
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