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Although piperacillin sodium has been successfully used in avian medicine for many years because of its broad spectrum antibacterial properties, (2) piperacillin sodium/tazobactam sodium injectable (Zosyn, Wyeth, Philadelphia, PA, USA) was approved by the Food and Drug Administration in 1994 and is actually a superior product to piperacillin alone because of the addition of the [beta]-lactamase inhibitor tazobactam.
Among them, predominant organisms were Gram-negative bacilli with Pseudomonas (18 isolates) being most common organism with the highest sensitivity to piperacillin + tazobactam, imipenem and amikacin.
To evaluating the efficacy of the drug combination as an option for therapy all the isolates were tested for the bactericidal synergistic effect by using sulbactam and tazobactam incorporated in agar with meropenem or colistin E-test strip (Biomeurix, France) on plate, Different sets of MHA plates incorporated with Sulbactam or tazobactam were prepared for respective combination depending upon the MICs of the organisms to be tested, For example the isolates with MIC of 8, 16, 32, 64, 128, 256, and 512 pg/mL were plated on MHA agar media plates incorporated with 4, 8, 16, 32, 64, 128, and 256 [micro]g/mL of sulbactam or tazobactam respectively followed by E-test strip,
Piperacillin/ Tazobactam and Cefoperazone/Sulbactam are extensively used as beta-lactam/beta-lactamase inhibitor combination compounds for treatment of life threatening P.
This can be explained by the fact that AmpC [beta]-lactamase producers are more susceptible to tazobactam as compared to clavulanic acid (4).
Randomization placed 289 patients in the ertapenem group and 287 in the piperacillin plus tazobactam group.
Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa showed high sensitivity to Carbapenem and Piperacillin Tazobactam and Cefoperazone Tazobactam.
In group 4 (n=13), injection Ceftriaxone + Tazobactam @ 10 mg/ kg b.
Pseudomonas: monotherapy: cefepime, piperacillin/ tazobactam, meropenem/imipenem; colistin (should always be used with another agent, see below)
21) of two samples obtained from patients who received piperacillin-tazobactam (4 g of piperacillin/500 mg of tazobactam three times per day).
This trial enrolled 550 adult patients who were randomised 1: 1 to receive Vabomere (meropenem 2g - vaborbactam 2g) as a three-hour IV infusion every eight hours, or piperacillin 4g - tazobactam 500mg as a 30-minute IV infusion every eight hours, each for up to 10 days.