targeted therapy


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targeted therapy

A generic term for therapies that impact on a specific molecular pathway, target or ligand.

Examples
Gefitimib for non-small cell carcinoma of the lungs with mutations in epidermal growth factor receptor, and imatinib for GIST tumours with activating mutations in c-Kit.
References in periodicals archive ?
In a first published report of its kind on the subject, the study found that metastatic colorectal cancer patients with wild-type Kirsten Ras (KRAS) gene will likely have better survival rate upon receiving anti-epithelial growth factor receptors (EGFR) targeted therapy.
Oncologists, pathologists, and other medical specialists summarize recent developments in the understanding of tumor biology, elucidate the roles of targets and pathways involved in carcinogenesis, describe the current state-of-the-art anti-cancer therapy and point out the most promising areas of translational research and targeted therapy.
In combination with chemotherapy, Necitumumab has the potential to be the first targeted therapy used for cost-effective first-line treatment.
Although cytoreductive nephrectomy (CN) had been proven to be advantageous in the interferon era, there have not been any randomized, controlled trials demonstrating its utility in the current era of targeted therapy.
1,2) ALK-based targeted therapy may benefit some patients with lung adenocarcinoma who have the ALK rearrangement, predominantly never-smokers.
Washington, Dec 10 (ANI): A new study has pointed out that a combination of epigenetic therapy and molecular targeted therapy has promising results at combating advanced lung cancer.
From skin care techniques to dose modifications of cardiac medications, nurses need to be aware of the management required to care for patients receiving targeted therapy.
Aphton's anti-gastrin targeted therapy induces antibodies in patients that bind to both gastrin 17 and gly-gastrin and remove them from circulation before they can bind to the cancer cell and initiate cell growth.
New Targeted Therapy Finder-Lung Cancer transforms current understanding of lung cancer into personalized and actionable treatment recommendations
This compact guide could fit in the most pockets but contains easy-to-access information about over 140 targeted therapy agents for which clinical data is available.
Laurie Eisengart, Gary MacVicar, and Ximing Yang explain the molecular basis for targeted therapy against vascular endothelial growth factor and mTOR pathways in renal cell carcinoma, summarize the clinical trials demonstrating the effectiveness of these drugs, and describe the biomarkers clinically significant in patients treated with targeted therapy.
Forecast sales of every marketed cancer targeted therapy and immunotherapy in each of the seven major markets over the period 2009 to 2019

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