target lesion


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target lesion

Dermatology A lesion typical of erythema multiforme–EM in which a vesicle is surrounded by an often hemorrhagic maculopapule; EM is often self-limited, of acute onset, resolves in 3-6 wks, and has a cyclical pattern; EM lesions are 'multiform' and include macules, papules, vesicles, bullae Etiology Idiopathic or follow infections, drug therapy or occur in immunocompromised hosts

target lesion

characteristic skin lesion of erythema multiforme

lesion

any pathological or traumatic discontinuity of tissue or loss of function of a part. Lesion is a broad term, including wounds, sores, ulcers, tumors, cataracts and any other tissue damage. They range from the skin sores associated with eczema to the changes in lung tissue that occur in tuberculosis.
Enlarge picture
Terms describing distribution of lesions. By permission from Slauson DO, Cooper BJ, Mechanisms of Disease: A Textbook of Comparative General Pathology, Mosby, 2001

target lesion
see target lesion.

target

1. an object or area toward which something is directed, e.g. target animal, population, level or nucleotide sequence.
2. the area of the anode of an x-ray tube where the electron beam collides causing the emission of x-rays.
3. a cell or organ that is affected by a particular agent, e.g. a hormone or drug.

target cell
see target cell.
target-film distance
the distance from the target of the x-ray tube and the plane of the x-ray film.
target lesion
skin lesion consisting of annular or arciform areas of erythema with central pigmentation. Associated with bacterial hypersensitivity and seborrheic dermatitis. Called also bull's eye lesion.
performance target
in herd health programs target performances are set up in a number of production and health functions in order to provide an incentive and give some measure of performance other than an absolute one. This enables farmers to be rated on their effective performance in spite of the great variations that can occur between them in basic resources.
References in periodicals archive ?
The ultrasound probe was rotated to the side of the target lesion and advanced deeper into the rectum until the basal boundaries of the prostate and the seminal vesicles became visible.
Additionally, a tough fascial layer may exist between the skin entry site and the target lesion that can be traversed once with the introducer to avoid having to cross this tough tissue multiple times with the biopsy needle.
The primary end point was target vessel failure (TVF), a composite of cardiac death, target vessel MI, clinically driven target vessel revascularization (defined as a repeated revascularization due to either a >50% restenosis in the treated lesion with symptoms of ischemia or for a >70% restenosis with or without symptoms within the entire major coronary vessel proximal and distal to a target lesion, including upstream and downstream branches and the target lesion itself).
Clinical data presented on more than 1,000 patients treated with the Tryton stent has demonstrated consistent target lesion revascularization rates of less than four percent and low thrombosis rates at six-month follow up and beyond.
More than one-third of sarcoma patients achieved a partial response for the target lesion and 61% had prolonged stable disease.
Its design is based on that of the Fhsseo-18 PTA catheter, which is coated with a matrix of anti-proliferative paclitaxel and a biocompatible excipient--enabling an optimal drug transfer to the target lesion tissue.
The primary endpoint was TLF at one year, which was a composite of cardiac death, target vessel myocardial infarction and clinically indicated target lesion revascularization.
There was also a 75% reduction in the need for target lesion revascularization in those with sirolimus-eluting stents, compared with the uncoated-stent group.
Stage III subjects experienced a substantially higher target lesion response rate (60% OR and 79% disease control) versus Stage IV subjects (22% and 33%, respectively);
In line with the one- and two-year data, we saw a consistently low clinically-driven target lesion revascularization rate and high patency rate.
s (NASDAQ: CSII) Diamondback 360 Coronary Orbital Atherectomy System demonstrated a high freedom from major adverse cardiac events rate, including target lesion revascularisation and target vessel revascularisation for the treatment of severely calcified lesions in coronary artery disease patients, the company said on Thursday.
The primary endpoint of the Excella III trial is target lesion failure, a composite measure of safety and effectiveness at 12 months defined as cardiac death, myocardial infarction related to the target vessel, and clinically-indicated target lesion revascularization.